{"id":"W4311139822","doi":"10.1016/j.iotech.2022.100303","title":"191P Preliminary biomarker and safety results of SQZ-PBMC-HPV at RP2D in monotherapy and combination with checkpoint inhibitors in HLA A*02+ patients with recurrent, locally advanced, or metastatic HPV16+ solid tumors","year":2022,"lang":"en","type":"article","venue":"Immuno-Oncology Technology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Internal medicine; Oncology; Pharmacodynamics; Immunotherapy; Peripheral blood mononuclear cell; Cancer; Antigen; Immunology; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002963032,0.0002363975,0.0004246086,0.0004432384,0.0001140893,0.00000530174,0.0001826519,0.000155694,0.00001562399],"category_scores_gemma":[0.00007111226,0.000188582,0.00002671178,0.0005046342,0.0005826889,0.00001454662,0.0004317962,0.0002560594,3.939684e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003180745,"about_ca_system_score_gemma":0.0003003437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002097034,"about_ca_topic_score_gemma":0.002521774,"domain_scores_codex":[0.9981999,0.0001913148,0.0005075209,0.0005578337,0.000169537,0.0003738362],"domain_scores_gemma":[0.999178,0.00005312336,0.0002984247,0.0003354205,0.00008542671,0.00004961968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2630638,0.00504588,0.2482508,0.0001536896,0.0007315502,0.0004776891,0.0009478804,0.0002834555,0.09538902,0.00007039359,0.0004379063,0.3851479],"study_design_scores_gemma":[0.1749534,0.1714712,0.4575165,0.0003688645,0.0001294496,0.0008377004,0.003581956,0.0003840369,0.1654673,0.0009047493,0.02290594,0.001478871],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953519,0.002689352,0.00002258615,0.0004816973,0.00004551518,0.001120433,0.0001198247,0.00001612262,0.0001526014],"genre_scores_gemma":[0.997711,0.0007707746,0.0005650522,0.00003522769,0.000002985021,0.0004690239,0.0003433122,0.00002894616,0.00007366615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.383669,"threshold_uncertainty_score":0.7690153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007143621557407641,"score_gpt":0.2751821166317269,"score_spread":0.2680384950743192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}