{"id":"W4311139822","doi":"10.1016/j.iotech.2022.100303","title":"191P Preliminary biomarker and safety results of SQZ-PBMC-HPV at RP2D in monotherapy and combination with checkpoint inhibitors in HLA A*02+ patients with recurrent, locally advanced, or metastatic HPV16+ solid tumors","year":2022,"lang":"en","type":"article","venue":"Immuno-Oncology Technology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Internal medicine; Oncology; Pharmacodynamics; Immunotherapy; Peripheral blood mononuclear cell; Cancer; Antigen; Immunology; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007819706,0.0004418864,0.0008051628,0.0002926267,0.0001933431,0.0005359356,0.0001864393,0.0005235042,0.002606778],"category_scores_gemma":[0.0009479481,0.0001399883,0.0007038296,0.0002611844,0.0002640865,0.0003674331,0.0001475161,0.001120274,0.0005967239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003993223,"about_ca_system_score_gemma":0.0003484519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004153785,"about_ca_topic_score_gemma":0.0005981404,"domain_scores_codex":[0.9996327,0.0001140004,0.00002531857,0.00008138992,0.00008699863,0.00005958687],"domain_scores_gemma":[0.9993506,0.0002240973,0.0001251451,0.00006188076,0.0001095375,0.0001288067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.136098,0.008276695,0.07803444,0.0007889768,0.001490855,0.002044616,0.0003976846,0.00455165,0.4535925,0.0004461666,0.006216309,0.308062],"study_design_scores_gemma":[0.009678215,0.4689907,0.1867783,0.0001140399,0.002858482,0.005660628,0.0002976678,0.007119543,0.2837333,0.000891157,0.0337625,0.000115374],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837837,0.005418576,0.002359274,0.0007203835,0.0001530798,0.0003484391,0.001948676,0.0001599453,0.005108106],"genre_scores_gemma":[0.9924585,0.0008748559,0.0009008076,0.0003880188,0.00008518514,0.0001535438,0.002379373,0.00002369733,0.002736081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002606778,"threshold_uncertainty_score":0.008720517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007143621557407641,"score_gpt":0.2751821166317269,"score_spread":0.2680384950743192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}