{"id":"W4311140049","doi":"10.1016/j.isci.2022.105783","title":"Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD","year":2022,"lang":"en","type":"article","venue":"iScience","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Institute of Infection and Immunity; Basic Energy Sciences; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; U.S. Military HIV Research Program; Canadian Institutes of Health Research; Uniformed Services University of the Health Sciences; Office of Science; National Institutes of Health; World Meteorological Organization; National Research Council Canada; Ministère de l'Économie, de l’Innovation et des Exportations du Québec; Fonds de Recherche du Québec - Santé; Mitacs; Ministère de la Santé et des Services sociaux; Genome Canada; Canada Foundation for Innovation; Biological and Environmental Research; Fondation du CHUM; SLAC National Accelerator Laboratory; CRC Health Group; Argonne National Laboratory; U.S. Department of Energy","keywords":"Epitope; Antibody; Virology; Neutralization; In vivo; In vitro; Epitope mapping; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Chemistry; Coronavirus disease 2019 (COVID-19); Immunology; Medicine; Biochemistry; Genetics; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001416774,0.0002168312,0.0001518068,0.00009362966,0.00009787319,0.0001526229,0.000201697,0.0003587544,0.002016552],"category_scores_gemma":[0.0001402134,0.00007740506,0.0002185982,0.00004432383,0.0001519381,0.0001310196,0.00008149236,0.0005245733,0.0002622276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002746502,"about_ca_system_score_gemma":0.0002710143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000423705,"about_ca_topic_score_gemma":0.0003443957,"domain_scores_codex":[0.9999353,0.00001351877,0.000004368507,0.000008672731,0.00001084652,0.00002725338],"domain_scores_gemma":[0.9999316,0.00001734502,0.00001552404,0.000007324293,0.00001136982,0.00001696925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007618639,0.00018437,0.002850696,0.00004281189,0.0000181541,0.0002420537,0.0000254146,0.0003908179,0.9889402,0.0009854421,0.0001878195,0.005370378],"study_design_scores_gemma":[0.0005084384,0.00533061,0.0606918,0.00003464943,0.00007312402,0.003704241,0.0001253592,0.005630963,0.9166843,0.000598453,0.006607444,0.00001065446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952407,0.0007489757,0.001232476,0.0001593873,0.00002493577,0.00003699754,0.0002700959,0.00003187022,0.002254518],"genre_scores_gemma":[0.9985718,0.0002150486,0.0004714845,0.00006545689,0.000007630251,0.00001321583,0.0002702321,0.000002910817,0.0003821939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002016552,"threshold_uncertainty_score":0.006745994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05392412774590721,"score_gpt":0.3779583820543287,"score_spread":0.3240342543084215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}