{"id":"W4311140049","doi":"10.1016/j.isci.2022.105783","title":"Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD","year":2022,"lang":"en","type":"article","venue":"iScience","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Institute of Infection and Immunity; Basic Energy Sciences; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; U.S. Military HIV Research Program; Canadian Institutes of Health Research; Uniformed Services University of the Health Sciences; Office of Science; National Institutes of Health; World Meteorological Organization; National Research Council Canada; Ministère de l'Économie, de l’Innovation et des Exportations du Québec; Fonds de Recherche du Québec - Santé; Mitacs; Ministère de la Santé et des Services sociaux; Genome Canada; Canada Foundation for Innovation; Biological and Environmental Research; Fondation du CHUM; SLAC National Accelerator Laboratory; CRC Health Group; Argonne National Laboratory; U.S. Department of Energy","keywords":"Epitope; Antibody; Virology; Neutralization; In vivo; In vitro; Epitope mapping; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Chemistry; Coronavirus disease 2019 (COVID-19); Immunology; Medicine; Biochemistry; Genetics; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001083715,0.0001531216,0.0003125884,0.0003154395,0.0003694406,0.00003458717,0.0003787986,0.00003140451,0.00000390495],"category_scores_gemma":[0.0004399291,0.0001448877,0.0001819853,0.001105652,0.0001994587,0.0002147228,0.0003372726,0.0002618652,0.00000461829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009804455,"about_ca_system_score_gemma":0.000363543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003005917,"about_ca_topic_score_gemma":0.000008783759,"domain_scores_codex":[0.9978606,0.00009259949,0.0002404998,0.0004798431,0.0007768909,0.000549639],"domain_scores_gemma":[0.9992114,0.0001901438,0.0001350687,0.0003064013,0.00013264,0.00002435299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009067884,0.0001327852,0.08378924,0.0001371632,0.000008900289,0.00004610236,0.0002956812,0.00001072567,0.9127217,0.0001861578,0.0001872074,0.002393686],"study_design_scores_gemma":[0.0006795237,0.0003430257,0.005853471,0.00001516158,0.0000429885,0.00001332941,0.0001880615,0.002973497,0.9863534,0.0001403915,0.003237619,0.0001595547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955212,0.0006070161,0.001718396,0.0002949171,0.0001995664,0.0004546669,0.0000281878,0.0000489911,0.001127067],"genre_scores_gemma":[0.9951024,0.000006092427,0.001157236,0.003546958,0.0001030824,0.00005398134,0.00000123427,0.0000196635,0.000009357561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07793576,"threshold_uncertainty_score":0.590835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05392412774590721,"score_gpt":0.3779583820543287,"score_spread":0.3240342543084215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}