{"id":"W4311156291","doi":"10.3390/cells11244019","title":"Selective Menin Deletion in the Hippocampal CA1 Region Leads to Disruption of Contextual Memory in the MEN1 Conditional Knockout Mouse: Behavioral Restoration and Gain of Function following the Reintroduction of MEN1 Gene","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Neuroscience; MEN1; Hippocampus; Conditional gene knockout; Cholinergic; Glutamatergic; Fear conditioning; Knockout mouse; Gene knockout; Hippocampal formation; Biology; Psychology; Gene; Phenotype; Genetics; Amygdala; Receptor; Glutamate receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001919195,0.0008788494,0.0004063973,0.0006564792,0.0003425308,0.0003720933,0.0005399887,0.000508407,0.002681873],"category_scores_gemma":[0.0001249362,0.0003186472,0.0003820232,0.0001864923,0.0007712764,0.0003545583,0.000449444,0.001027845,0.0005246414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003889166,"about_ca_system_score_gemma":0.000311687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001107856,"about_ca_topic_score_gemma":0.002593283,"domain_scores_codex":[0.9997674,0.00002199733,0.00002981202,0.00007783893,0.0000521415,0.00005094462],"domain_scores_gemma":[0.9997596,0.00002923785,0.00007935258,0.00001954967,0.00001072304,0.0001015151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008139129,0.00001999558,0.00008268579,0.00001999737,0.000004031996,0.00007547058,0.00001919541,0.00004323805,0.9991959,0.0000917154,0.00001350169,0.0003528856],"study_design_scores_gemma":[0.0000153274,0.00016535,0.002934674,0.00001057837,0.00001928392,0.0002967605,0.0000428944,0.0005075785,0.9948854,0.00006991825,0.001045909,0.000006346867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932214,0.0009227879,0.00377729,0.0001552545,0.00005367242,0.00003213018,0.0006462219,0.0001594839,0.001031884],"genre_scores_gemma":[0.9843928,0.001104928,0.004364753,0.00008545604,0.00001842717,0.00006668373,0.0005898165,0.0001042826,0.009272881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002681873,"threshold_uncertainty_score":0.00897181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01477347589438302,"score_gpt":0.2705630928436764,"score_spread":0.2557896169492934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}