{"id":"W4311156291","doi":"10.3390/cells11244019","title":"Selective Menin Deletion in the Hippocampal CA1 Region Leads to Disruption of Contextual Memory in the MEN1 Conditional Knockout Mouse: Behavioral Restoration and Gain of Function following the Reintroduction of MEN1 Gene","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Neuroscience; MEN1; Hippocampus; Conditional gene knockout; Cholinergic; Glutamatergic; Fear conditioning; Knockout mouse; Gene knockout; Hippocampal formation; Biology; Psychology; Gene; Phenotype; Genetics; Amygdala; Receptor; Glutamate receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00121278,0.0001017336,0.0001481388,0.00007243494,0.0001057208,0.000006162125,0.0001464711,0.00006072191,0.000005443033],"category_scores_gemma":[0.00005142949,0.00007225266,0.00006238224,0.0002484806,0.00007836367,0.00001134279,0.00006211831,0.0001689913,2.861237e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006477149,"about_ca_system_score_gemma":0.00005300561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001546351,"about_ca_topic_score_gemma":0.0001751154,"domain_scores_codex":[0.9982834,0.0007400583,0.0003484753,0.0002270925,0.0002847003,0.000116288],"domain_scores_gemma":[0.9994167,0.00005144029,0.000220738,0.00022435,0.00007454526,0.00001222621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000372071,0.000196369,0.001260997,0.000008281062,0.00001762183,2.27537e-7,0.003340363,0.003459458,0.9895337,0.00007157712,0.001070808,0.0006685907],"study_design_scores_gemma":[0.00121339,0.001646987,0.006644792,0.00001066903,0.00007485152,0.00001227247,0.01202616,0.000147253,0.9777117,0.00007428765,0.0003146741,0.0001229728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976369,0.0002192521,0.0009178927,0.000339919,0.0001398948,0.000686552,0.00002119896,0.000002342825,0.00003604235],"genre_scores_gemma":[0.9993452,0.00002529184,0.00004632633,0.0000690197,0.0001019093,0.0001242928,0.0002163896,0.000009265947,0.00006224448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01182195,"threshold_uncertainty_score":0.2946378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01477347589438302,"score_gpt":0.2705630928436764,"score_spread":0.2557896169492934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}