{"id":"W4311161233","doi":"10.3390/cancers14235943","title":"Immunogenic Death of Hepatocellular Carcinoma Cells in Mice Expressing Caspase-Resistant ROCK1 Is Not Replicated by ROCK Inhibitors","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Cancer Research UK","keywords":"ROCK1; Necroptosis; Programmed cell death; Cytotoxic T cell; CD8; Apoptosis; Cancer research; Biology; Immune system; Immunology; Medicine; Kinase; Protein kinase A; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004421866,0.0007459195,0.0007915232,0.00100612,0.0003264336,0.0005620256,0.0004433218,0.0008520336,0.003377585],"category_scores_gemma":[0.0003043166,0.0004876291,0.0008212642,0.0003280393,0.000700073,0.0005917427,0.0002764429,0.002445651,0.0009860857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005792174,"about_ca_system_score_gemma":0.0004299569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007054869,"about_ca_topic_score_gemma":0.001211011,"domain_scores_codex":[0.9992254,0.0001318665,0.00009046259,0.0001624959,0.0001621273,0.0002276966],"domain_scores_gemma":[0.9991925,0.0001021215,0.0002668475,0.0001313751,0.00005393133,0.0002531862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008122995,0.0002904241,0.0002256766,0.00004783726,0.00001348365,0.00009753265,0.00003893083,0.00009010898,0.9971647,0.000205593,0.00007893374,0.000934564],"study_design_scores_gemma":[0.0001730345,0.003219631,0.00441716,0.00001747123,0.00004032962,0.0005664883,0.00007772278,0.001668411,0.987889,0.0001096186,0.001805346,0.00001589986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941372,0.0007532824,0.001818196,0.0002984054,0.00009325151,0.0001012143,0.0008695383,0.0002405198,0.001688459],"genre_scores_gemma":[0.9866012,0.0006969581,0.002363751,0.0001503072,0.00004639101,0.0002693478,0.00120837,0.00008892566,0.008574883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003377585,"threshold_uncertainty_score":0.01129913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01628003378110129,"score_gpt":0.2245203398064739,"score_spread":0.2082403060253726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}