{"id":"W4311165255","doi":"10.1182/blood-2022-171751","title":"Consolidation Therapy with Blinatumomab Improves Overall Survival in Newly Diagnosed Adult Patients with B-Lineage Acute Lymphoblastic Leukemia in Measurable Residual Disease Negative Remission: Results from the ECOG-ACRIN E1910 Randomized Phase III National Cooperative Clinical Trials Network Trial","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Medicine; Blinatumomab; Minimal residual disease; Internal medicine; Induction chemotherapy; Chemotherapy regimen; Chemotherapy; Rituximab; Oncology; Gastroenterology; Surgery; Leukemia; Lymphoblastic Leukemia; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002081517,0.0009087138,0.001406944,0.0002271261,0.0002824595,0.0008641433,0.0007257689,0.0007806062,0.002307631],"category_scores_gemma":[0.0009739593,0.0003399886,0.001074631,0.0003348454,0.0005627606,0.000642907,0.0003635303,0.00228117,0.0005672497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006789048,"about_ca_system_score_gemma":0.001063555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005929249,"about_ca_topic_score_gemma":0.001895714,"domain_scores_codex":[0.9995275,0.0002747852,0.00003276666,0.00006136007,0.00004150536,0.00006223121],"domain_scores_gemma":[0.9992303,0.0001360662,0.0002453683,0.00007209962,0.00003536136,0.0002807592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.905822,0.0188719,0.01114124,0.000590661,0.001405566,0.00009215442,0.0001149425,0.001024733,0.006520096,0.0001387942,0.002244519,0.05203332],"study_design_scores_gemma":[0.7359797,0.2283647,0.02922448,0.0001091127,0.001244192,0.0002044107,0.00004583322,0.0007142426,0.001334934,0.0002023331,0.002556069,0.00002005476],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926577,0.003471366,0.0002183371,0.0004800348,0.0001140215,0.001204752,0.0006905592,0.00004876956,0.001114363],"genre_scores_gemma":[0.9910076,0.002696408,0.000774749,0.0008757265,0.0001737015,0.001560291,0.001893665,0.00001478975,0.001003133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002307631,"threshold_uncertainty_score":0.0110082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04284867665052221,"score_gpt":0.3463355024982483,"score_spread":0.3034868258477261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}