{"id":"W4311180475","doi":"10.1371/journal.pone.0277512","title":"The C4EB study—Transvamix (10% THC / 5% CBD) to treat chronic pain in epidermolysis bullosa: A protocol for an explorative randomized, placebo controlled, and double blind intervention crossover study","year":2022,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Dystrophic Epidermolysis Bullosa Research Association","keywords":"Medicine; Randomized controlled trial; Placebo; Crossover study; Quality of life (healthcare); McGill Pain Questionnaire; Psychological intervention; Clinical trial; Physical therapy; Adverse effect; Chronic pain; Visual analogue scale; Psychiatry; Internal medicine; Pathology; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009399398,0.003956762,0.006789906,0.001354742,0.002304354,0.002033531,0.003057277,0.005412616,0.02599592],"category_scores_gemma":[0.005503958,0.002515958,0.002879905,0.001510253,0.002149226,0.001761047,0.001139544,0.00458896,0.007273188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001491241,"about_ca_system_score_gemma":0.005758578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001545546,"about_ca_topic_score_gemma":0.002907799,"domain_scores_codex":[0.9952688,0.002310193,0.0004845251,0.000675139,0.0006100609,0.0006512311],"domain_scores_gemma":[0.9977911,0.0003969617,0.0003836643,0.0003506568,0.0004746825,0.0006028863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9194732,0.04070371,0.0007280574,0.005095079,0.0007809802,0.0002520369,0.0002365627,0.0006183184,0.006239158,0.001225662,0.005780553,0.01886667],"study_design_scores_gemma":[0.9099564,0.07038473,0.002515521,0.0005262694,0.0004910611,0.00007116919,0.00006668508,0.000423822,0.0007230308,0.0005770636,0.01419262,0.00007166721],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.03872462,0.001676026,0.002515535,0.000407323,0.0005526888,0.9506561,0.002911209,0.0001860291,0.002370553],"genre_scores_gemma":[0.02547102,0.001266056,0.003995378,0.0006393905,0.0001803055,0.9655735,0.0007836551,0.00002235227,0.002068389],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02599592,"threshold_uncertainty_score":0.08696496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09384335982352436,"score_gpt":0.3816554177215504,"score_spread":0.287812057898026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}