{"id":"W4311194927","doi":"10.1158/1538-7445.cancepi22-b002","title":"Abstract B002: A CRISPR/Cas9 screening strategy for identifying modifiers of the viral mimicry response","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Biology; Molecular mimicry; Cell biology; Trans-activating crRNA; Interferon; CRISPR; Genetics; Immune system; Cas9; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003870683,0.0006661145,0.00064362,0.000643766,0.0004146259,0.0007728434,0.0007116846,0.0009690348,0.004040253],"category_scores_gemma":[0.0004008682,0.000334848,0.0004693676,0.0003627491,0.0003266696,0.0003109832,0.0005994073,0.001079925,0.001622027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004178571,"about_ca_system_score_gemma":0.0004647253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00122021,"about_ca_topic_score_gemma":0.001492577,"domain_scores_codex":[0.9993815,0.00005054283,0.00006320939,0.0001638505,0.0002609085,0.00007990126],"domain_scores_gemma":[0.9998158,0.00002973112,0.00004041053,0.00002122636,0.00004629694,0.00004671326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006843123,0.00004697199,0.00007954211,0.00005796483,0.000007866879,0.000118321,0.0000113113,0.0002708452,0.9935222,0.0003219447,0.0003253584,0.005169275],"study_design_scores_gemma":[0.00003090676,0.000284132,0.0006645998,0.00001154213,0.00002627667,0.0004093397,0.00001829008,0.006111391,0.9826891,0.000114206,0.009608858,0.0000313088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.65998,0.004455938,0.2855172,0.001317233,0.0007594724,0.001822554,0.005872449,0.006160155,0.03411499],"genre_scores_gemma":[0.8384479,0.001726484,0.1346241,0.0005671844,0.00003614375,0.0004828346,0.003902369,0.0004889421,0.01972403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004040253,"threshold_uncertainty_score":0.01351595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1143496711698376,"score_gpt":0.4658976351301807,"score_spread":0.351547963960343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}