{"id":"W4311201147","doi":"10.1001/jamaneurol.2022.4485","title":"Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission Tomography","year":2022,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":265,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Wallenberg Centre for Molecular and Translational Medicine; UK Dementia Research Institute; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Universidade Federal do Rio Grande do Sul; Directorate for Biological Sciences; Sahlgrenska Universitetssjukhuset; Erasmus Universiteit Rotterdam; Göteborgs Universitet; King's College London; Canadian Institutes of Health Research; National Institute for Health and Care Research; University of Pittsburgh","keywords":"Positron emission tomography; Dementia; Biomarker; Medicine; Magnetic resonance imaging; Standardized uptake value; Cerebrospinal fluid; Internal medicine; Neuroimaging; Tau protein; Oncology; Alzheimer's Disease Neuroimaging Initiative; Psychology; Alzheimer's disease; Nuclear medicine; Pathology; Disease; Chemistry; Psychiatry; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007907288,0.0002735303,0.000470966,0.0007668938,0.0003051535,0.00002711405,0.0002250201,0.0002466984,0.0008267206],"category_scores_gemma":[0.0001111042,0.0002351341,0.0002526687,0.001430646,0.0001172976,0.0001235431,0.0002232595,0.0009577498,0.00000575836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001080678,"about_ca_system_score_gemma":0.000155513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001743626,"about_ca_topic_score_gemma":0.00000698849,"domain_scores_codex":[0.9965336,0.0006588366,0.0004412748,0.0006017358,0.001099212,0.0006653595],"domain_scores_gemma":[0.9985064,0.0002008889,0.0003737636,0.0003435346,0.0003081989,0.0002672503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01230743,0.0006000493,0.7124071,0.00006687437,0.0004453147,0.000173173,0.0001183871,0.000006071351,0.2587996,0.00001029421,0.01206496,0.003000668],"study_design_scores_gemma":[0.006441737,0.01417575,0.8673061,0.00004587685,0.0004026637,0.0001496104,0.0001214965,0.000310382,0.09905207,0.00004684354,0.01170789,0.0002395569],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865844,0.0002418533,0.00003467219,0.009201697,0.0002008095,0.0008578005,0.00004333449,0.0001075928,0.002727898],"genre_scores_gemma":[0.9958119,0.00006385146,0.00006837684,0.001920072,0.00007545105,0.0001106676,0.0002688239,0.00004681989,0.001634085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1597476,"threshold_uncertainty_score":0.9588492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005020105935330478,"score_gpt":0.2411105542890304,"score_spread":0.2360904483537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}