{"id":"W4311201803","doi":"10.1002/alz.12827","title":"Strategic white matter hyperintensity locations for cognitive impairment: A multicenter lesion‐symptom mapping study in 3525 memory clinic patients","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Pfizer; Biogen; BioClinica; Alzheimer Nederland; Eisai; ZonMw; Universitair Medisch Centrum Utrecht; Austrian Science Fund; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Medical Research Council; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Hyperintensity; Cognition; White matter; Voxel; Memory clinic; Lesion; Medicine; Psychology; Audiology; Cardiology; Cognitive impairment; Neuroscience; Radiology; Psychiatry; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008745039,0.0005836227,0.0005166799,0.001018721,0.0008223785,0.0008085785,0.00047163,0.0004910869,0.001119745],"category_scores_gemma":[0.00190105,0.0003552476,0.000470544,0.0008722188,0.0004625945,0.0004542579,0.000756008,0.0002936753,0.0002645926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004302071,"about_ca_system_score_gemma":0.0003247091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006071672,"about_ca_topic_score_gemma":0.008148329,"domain_scores_codex":[0.9995775,0.0001050201,0.00004460544,0.0001683647,0.00004758098,0.0000570601],"domain_scores_gemma":[0.9991705,0.0001018403,0.0003655822,0.0001149815,0.00007060289,0.0001764805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004223973,0.00008552721,0.9953544,0.00001537329,0.0001655124,0.0002959155,0.000372264,0.00008991521,0.001085884,0.0000242294,0.0001360122,0.001952629],"study_design_scores_gemma":[0.00003196816,0.0002626621,0.9982744,0.000006676912,0.00008614686,0.0006439181,0.0002377584,0.0001818056,0.000131152,0.00002957435,0.0001069958,0.000006813884],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997303,0.00004927608,0.00005183713,0.000006135792,8.249563e-7,0.00000866339,0.0001011522,0.00000222656,0.00004957341],"genre_scores_gemma":[0.9997414,0.00001282935,0.00005873343,0.000009853962,0.000002208419,0.000006563097,0.0001408908,0.000001054208,0.00002641049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006071672,"threshold_uncertainty_score":0.01207268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06580756245983084,"score_gpt":0.3422253666444816,"score_spread":0.2764178041846507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}