{"id":"W4311202307","doi":"10.1080/21678421.2022.2154678","title":"MiToS and King’s staging as clinical outcome measures in ALS: a retrospective analysis of the FORTITUDE-ALS trial","year":2022,"lang":"en","type":"article","venue":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Cytokinetics; Astellas Pharma US","keywords":"Medicine; Hazard ratio; Stage (stratigraphy); Placebo; Amyotrophic lateral sclerosis; Randomized controlled trial; Retrospective cohort study; Confidence interval; Post-hoc analysis; Surgery; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0099742,0.0006239625,0.001579657,0.0002930145,0.0003018424,0.0009513539,0.0004406346,0.0005538278,0.001520027],"category_scores_gemma":[0.01031354,0.0003338747,0.001848098,0.0007230806,0.0003945604,0.0008415759,0.0004900657,0.0008715775,0.0001887318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003500159,"about_ca_system_score_gemma":0.0004893519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004354446,"about_ca_topic_score_gemma":0.0007362559,"domain_scores_codex":[0.9920217,0.005649585,0.0007340225,0.000662488,0.0006822972,0.0002498806],"domain_scores_gemma":[0.9894537,0.003772104,0.004565367,0.001232189,0.0005697951,0.0004068849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6205617,0.0008285352,0.3101664,0.002959491,0.02090787,0.0001966906,0.0002812881,0.001776835,0.002101415,0.001079794,0.00392271,0.0352172],"study_design_scores_gemma":[0.1036792,0.04895677,0.798848,0.0009763193,0.02661877,0.0008136081,0.0004355382,0.004388998,0.001685129,0.001774337,0.01163191,0.0001914123],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757628,0.0188051,0.0009463069,0.0002607454,0.00009905721,0.0005360902,0.002116945,0.00001565498,0.001457153],"genre_scores_gemma":[0.9944438,0.001806763,0.0004428036,0.0001691051,0.0001461856,0.0004520827,0.002171705,0.000009956446,0.0003575635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0099742,"threshold_uncertainty_score":0.05274922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.11010140452826,"score_gpt":0.3602907664029132,"score_spread":0.2501893618746532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}