{"id":"W4311202854","doi":"10.1007/s11357-022-00704-2","title":"Network analyses unveil ageing-associated pathways evolutionarily conserved from fungi to animals","year":2022,"lang":"en","type":"article","venue":"GeroScience","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Sorbonne Université","keywords":"Longevity; Biology; Pleiotropy; Ageing; Evolutionary biology; Convergent evolution; Conserved sequence; Druggability; Model organism; Tree of life (biology); Phylogenetics; Genetics; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003841408,0.000517464,0.0003975965,0.001509432,0.0004818717,0.0006905096,0.0003062083,0.0002718499,0.001880513],"category_scores_gemma":[0.001201323,0.0001325169,0.0005995313,0.001211787,0.0003932212,0.0009776084,0.0005705389,0.0005352364,0.0003474627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004128302,"about_ca_system_score_gemma":0.0004393742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001984211,"about_ca_topic_score_gemma":0.005019461,"domain_scores_codex":[0.9997866,0.00004137024,0.00001156305,0.00009790042,0.00002882049,0.0000337875],"domain_scores_gemma":[0.9992372,0.0002667769,0.0002100452,0.00008813594,0.00009111242,0.0001068402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001697022,0.0001918066,0.1980146,0.001658729,0.001697087,0.0010559,0.0007723332,0.03649893,0.5993534,0.02475927,0.003323475,0.1309774],"study_design_scores_gemma":[0.0001080174,0.0005970051,0.6443132,0.0003191606,0.002119239,0.001614458,0.001118266,0.1955645,0.04208076,0.07706916,0.03495602,0.0001403982],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9322264,0.004027484,0.05245946,0.0004938142,0.0000706783,0.00003300025,0.006178406,0.0004661233,0.004044707],"genre_scores_gemma":[0.9788527,0.001456826,0.01431442,0.00009245009,0.00002385954,0.00002742992,0.004427528,0.0000671435,0.000737697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001984211,"threshold_uncertainty_score":0.006290972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0503874168957874,"score_gpt":0.2738356579503448,"score_spread":0.2234482410545574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}