{"id":"W4311232415","doi":"10.20944/preprints202212.0206.v1","title":"SKI-1/S1P Facilitates SARS-CoV-2 Spike Induced Cell-To-Cell Fusion via Activation of Srebp-2 and Metalloproteases, Whereas PCSK9 Enhances the Degradation of ACE2","year":2022,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Cell biology; Furin; Proprotein convertase; Proprotein Convertases; Cell fusion; Cell; Chemistry; PCSK9; Cell culture; Biology; LDL receptor; Biochemistry; Cholesterol; Enzyme; Lipoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001276535,0.000373615,0.0003247555,0.0001751405,0.0001248662,0.0003013357,0.0001329344,0.0002337261,0.001280108],"category_scores_gemma":[0.00009623346,0.0001295626,0.000356571,0.0001103345,0.0001987064,0.000221992,0.0002132199,0.0005373901,0.0004497945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002747723,"about_ca_system_score_gemma":0.0002447072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006042528,"about_ca_topic_score_gemma":0.0008438907,"domain_scores_codex":[0.9998149,0.00003209435,0.00002164454,0.00002438863,0.00005235535,0.00005460527],"domain_scores_gemma":[0.9998877,0.00002365287,0.00003106263,0.00001539838,0.00001035119,0.00003178137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001241455,0.0000329898,0.00008847411,0.00001848089,0.000002857758,0.00002615322,0.00000817137,0.00002668998,0.9992157,0.0000455582,0.00002385421,0.000386807],"study_design_scores_gemma":[0.00001143673,0.0001763236,0.002439146,0.000001795655,0.000005167525,0.0001218055,0.00001512851,0.0005366143,0.9959371,0.00001833328,0.0007348696,0.000002226757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969445,0.0006420329,0.001118834,0.00008470596,0.00002150324,0.0000177067,0.0003102582,0.00004601226,0.0008144496],"genre_scores_gemma":[0.9952245,0.0003999452,0.00130109,0.00004200956,0.000009448621,0.00002573278,0.0007906535,0.00001406866,0.0021925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001280108,"threshold_uncertainty_score":0.004282355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.133449620199689,"score_gpt":0.3826263522996015,"score_spread":0.2491767320999125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}