{"id":"W4311237378","doi":"10.1007/s00401-022-02524-2","title":"LATE-NC staging in routine neuropathologic diagnosis: an update","year":2022,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; University of British Columbia; University Health Network","funders":"NIHR Cambridge Biomedical Research Centre; European Regional Development Fund; Instituto de Salud Carlos III; Medical Research Council; National Institutes of Health; BrightFocus Foundation; NOMIS Stiftung; Japan Agency for Medical Research and Development; Fonds Wetenschappelijk Onderzoek; Rossy Foundation; Alzheimer's Society; Alzheimer Forschung Initiative; Vlaamse regering; National Institute for Health and Care Research; Nancy and Buster Alvord Endowment; Alzheimer’s Disease Research Center, University of Washington; California Department of Public Health","keywords":"Frontotemporal lobar degeneration; Amyotrophic lateral sclerosis; Medical diagnosis; Lewy body; Medicine; Pathology; Dementia; Neuropathology; Disease; Frontotemporal dementia; Hippocampal sclerosis; Psychology; Neuroscience; Epilepsy; Temporal lobe","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0200738,0.001488011,0.002555229,0.008130221,0.00137088,0.003931897,0.005590633,0.003167643,0.001566923],"category_scores_gemma":[0.02416579,0.001018972,0.001405785,0.005234932,0.003729313,0.007623727,0.002719716,0.005333931,0.001875869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005424283,"about_ca_system_score_gemma":0.006761282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01785215,"about_ca_topic_score_gemma":0.02527624,"domain_scores_codex":[0.9954797,0.001197778,0.001300678,0.00064271,0.001100004,0.0002791556],"domain_scores_gemma":[0.9719849,0.007551406,0.001894434,0.0008940157,0.01639939,0.00127578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001081069,0.00006099562,0.01006038,0.004621261,0.0001269075,0.0005552864,0.0006108905,0.000802546,0.0008243342,0.005816966,0.1012909,0.8751214],"study_design_scores_gemma":[0.00005162727,0.0002303097,0.01906488,0.02184914,0.0006277199,0.01052312,0.001965781,0.003072697,0.001009763,0.01092463,0.9304253,0.0002549279],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005396289,0.9274627,0.01235723,0.03529128,0.01140977,0.0001341076,0.0004469483,0.0003829625,0.00711878],"genre_scores_gemma":[0.0412068,0.8860306,0.04082725,0.01199833,0.01534757,0.0002774411,0.001957769,0.0002203285,0.002133894],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0200738,"threshold_uncertainty_score":0.1061617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04368186244608344,"score_gpt":0.303189434999684,"score_spread":0.2595075725536006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}