{"id":"W4311237378","doi":"10.1007/s00401-022-02524-2","title":"LATE-NC staging in routine neuropathologic diagnosis: an update","year":2022,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; University of British Columbia; University Health Network","funders":"NIHR Cambridge Biomedical Research Centre; European Regional Development Fund; Instituto de Salud Carlos III; Medical Research Council; National Institutes of Health; BrightFocus Foundation; NOMIS Stiftung; Japan Agency for Medical Research and Development; Fonds Wetenschappelijk Onderzoek; Rossy Foundation; Alzheimer's Society; Alzheimer Forschung Initiative; Vlaamse regering; National Institute for Health and Care Research; Nancy and Buster Alvord Endowment; Alzheimer’s Disease Research Center, University of Washington; California Department of Public Health","keywords":"Frontotemporal lobar degeneration; Amyotrophic lateral sclerosis; Medical diagnosis; Lewy body; Medicine; Pathology; Dementia; Neuropathology; Disease; Frontotemporal dementia; Hippocampal sclerosis; Psychology; Neuroscience; Epilepsy; Temporal lobe","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001191808,0.0003275323,0.000532639,0.0003442939,0.000362303,0.00005816459,0.000622854,0.00008356896,0.001880642],"category_scores_gemma":[0.0005282053,0.0002694168,0.0001205596,0.0009441996,0.0001604407,0.0002379248,0.001106185,0.001541695,0.0000977595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001751566,"about_ca_system_score_gemma":0.000070034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004145653,"about_ca_topic_score_gemma":0.000003381099,"domain_scores_codex":[0.995231,0.001586303,0.0005370075,0.001011377,0.0007304745,0.0009037886],"domain_scores_gemma":[0.9984805,0.0001374825,0.000146351,0.0008820037,0.00006477108,0.0002888656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006966792,0.001624892,0.8015026,0.0000341254,0.000008591528,0.0305944,0.0004943737,0.0005827306,0.1561915,0.0001352504,0.0007889546,0.0073459],"study_design_scores_gemma":[0.001427614,0.002478058,0.9880348,0.00001756904,0.00002391393,0.0007071732,0.00009521658,0.0009956057,0.0003794581,0.0001833438,0.005364344,0.0002929416],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899573,0.0001230963,0.000006032491,0.007563434,0.0002113717,0.0006971596,0.00003956287,0.0003306288,0.001071471],"genre_scores_gemma":[0.9913008,0.0004607902,0.0002766642,0.006941664,0.0001118291,0.0004471586,0.00008255553,0.0000725693,0.0003059696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1865322,"threshold_uncertainty_score":0.9999758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04368186244608344,"score_gpt":0.303189434999684,"score_spread":0.2595075725536006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}