{"id":"W4311237385","doi":"10.1111/jnc.15739","title":"A single protective polymorphism in the prion protein blocks <scp>cross‐species</scp> prion replication in cultured cells","year":2022,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Natural Sciences and Engineering Research Council of Canada","keywords":"Hamster; Biology; Chinese hamster ovary cell; Transfection; Cricetulus; Fungal prion; Scrapie; Glycosylation; Cell culture; Virology; Prion protein; In vitro; Recombinant DNA; Mesocricetus; Gene; Cell biology; Genetics; Phenotype; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002246883,0.0002590807,0.0002915268,0.0001305284,0.0001396842,0.0002772292,0.0003061634,0.0002483141,0.0006799388],"category_scores_gemma":[0.0002202911,0.0001622714,0.0001841726,0.0001405562,0.0002609556,0.0001106089,0.0002287351,0.0004928297,0.0003569645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002270185,"about_ca_system_score_gemma":0.0002832726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009152793,"about_ca_topic_score_gemma":0.001471097,"domain_scores_codex":[0.9997038,0.00008631818,0.00004180377,0.00005793283,0.00006522839,0.00004491053],"domain_scores_gemma":[0.9996862,0.00009965886,0.00007658115,0.00006801914,0.00002131603,0.00004815879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003180951,0.00002353703,0.00006941339,0.000008186835,0.000002047736,0.00002770583,0.000007790395,0.0000198809,0.9995387,0.00003109318,0.0000111126,0.000228887],"study_design_scores_gemma":[0.00001631167,0.0006308873,0.002638096,0.000006588652,0.00001435407,0.0002571405,0.00002414816,0.0008336438,0.9944656,0.00001904198,0.001090297,0.000003852227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976286,0.0002527441,0.001122982,0.00002816598,0.00001248976,0.00002801772,0.0000958936,0.00003505942,0.0007961327],"genre_scores_gemma":[0.9967446,0.0002735366,0.001665199,0.00002848771,0.000009579771,0.00004278147,0.0003301949,0.00002221366,0.000883302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009152793,"threshold_uncertainty_score":0.002274632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246478106484633,"score_gpt":0.2438001930922513,"score_spread":0.2313354120274049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}