{"id":"W4311239449","doi":"10.1002/ana.26569","title":"Alzheimer's Disease Genetic Risk, Cognition, and Brain Aging in Midlife","year":2022,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institutes of Health; San Antonio Medical Foundation","keywords":"Apolipoprotein E; Hyperintensity; Cognition; Brain size; Dementia; Subclinical infection; Neuroimaging; Medicine; Confidence interval; Cognitive decline; Internal medicine; Psychology; Neuropsychology; Alzheimer's disease; Montreal Cognitive Assessment; Effects of sleep deprivation on cognitive performance; Disease; Gerontology; Magnetic resonance imaging; Psychiatry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005750708,0.0002313754,0.0002328011,0.0005400309,0.0003892423,0.0004574729,0.0002486036,0.0003897307,0.0008865631],"category_scores_gemma":[0.001766575,0.0002062578,0.0002502249,0.0004157929,0.0002098635,0.0002464992,0.0002900886,0.0003637412,0.0001372555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001816043,"about_ca_system_score_gemma":0.0001577488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00749289,"about_ca_topic_score_gemma":0.01438343,"domain_scores_codex":[0.9998463,0.00004814455,0.00001609373,0.00003992519,0.00002361966,0.00002586148],"domain_scores_gemma":[0.9993777,0.0001050772,0.0002310973,0.00005752235,0.00007530923,0.0001532041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002878235,0.00004664364,0.9976367,0.000006091475,0.00009163404,0.00006943662,0.00007501454,0.00002995805,0.0002898091,0.00002693995,0.00006515381,0.001374775],"study_design_scores_gemma":[0.000006538694,0.00007930219,0.9994973,0.00000234832,0.00002081319,0.0001107684,0.00004353614,0.00008694686,0.00003588851,0.00004342559,0.00007157533,0.000001576142],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994432,0.000191238,0.00004289889,0.00002886948,0.0000036945,0.00000210367,0.0001625828,0.00000129765,0.0001240385],"genre_scores_gemma":[0.9995271,0.00006247898,0.00008917785,0.00002018593,0.000006728099,0.00000296263,0.0001425346,6.024243e-7,0.000148225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00749289,"threshold_uncertainty_score":0.0148986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04993041483010306,"score_gpt":0.3553235008696164,"score_spread":0.3053930860395134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}