{"id":"W4311247417","doi":"10.1001/jamanetworkopen.2022.45596","title":"Association of Immune-Related Adverse Events, Hospitalization, and Therapy Resumption With Survival Among Patients With Metastatic Melanoma Receiving Single-Agent or Combination Immunotherapy","year":2022,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary","funders":"","keywords":"Medicine; Ipilimumab; Nivolumab; Adverse effect; Proportional hazards model; Internal medicine; Oncology; Melanoma; Retrospective cohort study; Immune checkpoint; Cohort; Survival analysis; Cancer; Metastatic melanoma; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004277464,0.0001527609,0.0002016961,0.0004320604,0.0002557027,0.0003194608,0.0002502433,0.0001934936,0.001060268],"category_scores_gemma":[0.001626677,0.00009443118,0.0002659299,0.0005364405,0.000200645,0.000175481,0.0002208181,0.0004282832,0.00007259344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000662133,"about_ca_system_score_gemma":0.0006941443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01659918,"about_ca_topic_score_gemma":0.03569214,"domain_scores_codex":[0.9997132,0.00004555065,0.00002800893,0.00006044629,0.00008829853,0.00006442296],"domain_scores_gemma":[0.9985597,0.0001728116,0.0007915839,0.00007895927,0.0001309721,0.0002660743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001063247,0.000009964561,0.9991021,0.000004731724,0.00002460098,0.00001858164,0.00000851664,0.00003034486,0.00006990291,0.00000330423,0.00004347583,0.0005781037],"study_design_scores_gemma":[0.000004584432,0.00006932279,0.9995353,0.000002903651,0.00001410838,0.00009458546,0.0000245005,0.0001536587,0.00002445428,0.000005992597,0.00006922812,0.000001310617],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990219,0.0002831405,0.0000424856,0.000033091,0.000003231633,0.000005634042,0.0003540539,0.000002981635,0.0002534284],"genre_scores_gemma":[0.9995141,0.00006817211,0.00002851544,0.00001175946,0.000006493286,0.000003419711,0.0002949972,5.855672e-7,0.00007208503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01659918,"threshold_uncertainty_score":0.03300512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01367996366534781,"score_gpt":0.2415432613721868,"score_spread":0.2278632977068389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}