{"id":"W4311268033","doi":"10.21203/rs.3.rs-2312251/v1","title":"A MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57Kip2 targeting","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Institute of Molecular and Cell Biology; Alleanza Contro il Cancro; Università degli Studi Roma Tre; Agency for Science, Technology and Research; Associazione Italiana per la Ricerca sul Cancro; Ministero della Salute; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"MyoD; Cancer research; SKP2; Carcinogenesis; Fusion protein; Rhabdomyosarcoma; Biology; Medicine; Cell biology; Internal medicine; Pathology; Cancer; Myogenesis; Genetics; Myocyte; Sarcoma; Ubiquitin; Recombinant DNA; Ubiquitin ligase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008597744,0.0003915543,0.0002544694,0.0002652113,0.0001265379,0.0002399715,0.0002013059,0.0002322382,0.001938578],"category_scores_gemma":[0.00005514951,0.0001520767,0.0002051813,0.0001202294,0.0002335842,0.0001763754,0.0002126281,0.0006338949,0.0005411642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003141695,"about_ca_system_score_gemma":0.0002740841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004623446,"about_ca_topic_score_gemma":0.001020661,"domain_scores_codex":[0.9999038,0.000008953556,0.000009874606,0.00002426427,0.00002605595,0.00002700006],"domain_scores_gemma":[0.999946,0.000004682092,0.00001344981,0.00000499321,0.000004535409,0.00002634862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002920509,0.00007842757,0.0001469397,0.00003828394,0.000006029895,0.00003800026,0.000006379276,0.00008030779,0.9973712,0.0001057233,0.0001326572,0.001704077],"study_design_scores_gemma":[0.00005667425,0.0004774045,0.00208394,0.000004093432,0.00001450482,0.0001082093,0.00001515492,0.0007903273,0.9938527,0.00003914854,0.002554399,0.000003502243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926629,0.001171897,0.001844147,0.0001742641,0.00006568907,0.00004147405,0.001204491,0.0004012834,0.002433924],"genre_scores_gemma":[0.9933373,0.0005574463,0.001254688,0.00005607005,0.0000111049,0.00005143771,0.001020567,0.00004231756,0.003669107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001938578,"threshold_uncertainty_score":0.006485224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05617576586876887,"score_gpt":0.3914184602446183,"score_spread":0.3352426943758494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}