{"id":"W4311275318","doi":"10.1158/1055-9965.epi-22-0861","title":"Genetic Predictors for Fecal Propionate and Butyrate-Producing Microbiome Pathway Are Not Associated with Colorectal Cancer Risk: A Mendelian Randomization Analysis","year":2022,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Cancer Care Ontario; Memorial University of Newfoundland","funders":"National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Institute on Aging; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; National Institute for Health and Care Research; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Health and Medical Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; Knut och Alice Wallenbergs Stiftelse; World Cancer Research Fund; Medical Research Council; Institut National de la Santé et de la Recherche Médicale; Canadian Cancer Society Research Institute; Chonnam National University Hwasun Hospital; Centers for Disease Control and Prevention; Xunta de Galicia; National Human Genome Research Institute; Cancer Council Victoria; School of Public Health, Imperial College London; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Centres de Recerca de Catalunya; Chonnam National University; Umeå Universitet; Vetenskapsrådet; Mutuelle Générale de l'Education Nationale; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Imperial College London; Generalitat de Catalunya; Canadian Institutes of Health Research; Cancerfonden; Institut Gustave-Roussy; University of South Florida; Conseil Régional des Pays de la Loire; University of Cambridge; Wageningen University and Research; Cancer Research UK; Moffitt Cancer Center; Pelotonia; Mike and Josie Harper Cancer Research Institute; National Institutes of Health; National Heart, Lung, and Blood Institute; Florida Department of Health; Memorial Sloan-Kettering Cancer Center; Johns Hopkins University; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Division of Cancer Prevention, National Cancer Institute; Association Anne de Bretagne Genetique; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Fred Hutchinson Cancer Research Center; U.S. Department of Health and Human Services; Office of Research Infrastructure Programs, National Institutes of Health; American Institute for Cancer Research; Damon Runyon Cancer Research Foundation","keywords":"Colorectal cancer; Medicine; Single-nucleotide polymorphism; Mendelian randomization; Butyrate; Genetic model; Internal medicine; Gut flora; Oncology; Cancer; Genetics; Genotype; Biology; Immunology; Gene; Genetic variants; Food science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03931031,0.001904364,0.002804529,0.001721424,0.0010052,0.001154608,0.001809368,0.001698937,0.004358037],"category_scores_gemma":[0.05277342,0.0007542382,0.007160662,0.001497591,0.001532525,0.0006770142,0.001007184,0.001182538,0.0003331323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006631776,"about_ca_system_score_gemma":0.00133783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003222421,"about_ca_topic_score_gemma":0.00191874,"domain_scores_codex":[0.9401909,0.04470813,0.002035828,0.008838393,0.002971969,0.001254719],"domain_scores_gemma":[0.9506056,0.03204741,0.005064802,0.01032754,0.001100003,0.0008546923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09138151,0.0008553345,0.7158406,0.001029883,0.08019677,0.004692052,0.001156367,0.01055821,0.02851025,0.01159077,0.002996726,0.05119152],"study_design_scores_gemma":[0.02040391,0.02044817,0.6431811,0.0003854299,0.06936498,0.009871824,0.0005407167,0.1956047,0.009091003,0.02204806,0.008611417,0.0004488451],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9250235,0.001601138,0.0690953,0.0005503496,0.0001962496,0.0007316765,0.00108714,0.0003842798,0.00133028],"genre_scores_gemma":[0.981437,0.0001425167,0.01677711,0.0001710883,0.00004970844,0.0004536603,0.0004727768,0.00006450682,0.0004317383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03931031,"threshold_uncertainty_score":0.2078953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01898215968527703,"score_gpt":0.2936623989430032,"score_spread":0.2746802392577261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}