{"id":"W4311288372","doi":"10.1128/jvi.01638-22","title":"Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates","year":2022,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; National Institute of Allergy and Infectious Diseases; Japan Agency for Medical Research and Development; Support Program for Starting up Innovation Hub; Foundation for the National Institutes of Health","keywords":"Antibody-dependent cell-mediated cytotoxicity; Biology; Cytotoxicity; Antibody; Human immunodeficiency virus (HIV); Neutralization; Virology; Immunology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001392056,0.0001942291,0.0002123785,0.0001149941,0.00009692843,0.0001358102,0.0001987876,0.000196178,0.001100135],"category_scores_gemma":[0.0001834444,0.00007708727,0.00009891663,0.00007891415,0.0001086903,0.00009933916,0.00009478908,0.0002775455,0.0002274099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001961703,"about_ca_system_score_gemma":0.0001667641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003739414,"about_ca_topic_score_gemma":0.0003428822,"domain_scores_codex":[0.999934,0.00001523803,0.000004130921,0.000009803702,0.00001753534,0.00001926508],"domain_scores_gemma":[0.9999566,0.00001013103,0.000008217416,0.000003254087,0.000009199217,0.000012581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002652211,0.0001094889,0.0003377915,0.00006803592,0.000008023118,0.0001164451,0.00002047712,0.0005674314,0.9931224,0.0000952871,0.0001091193,0.005180245],"study_design_scores_gemma":[0.0002480441,0.005022676,0.006106109,0.00001281123,0.00003679369,0.0008709705,0.00003134309,0.002898142,0.9780263,0.00004954618,0.006687963,0.000009209526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952137,0.001513888,0.001336019,0.00008604958,0.000009799706,0.0001184949,0.000259553,0.00002122589,0.001441234],"genre_scores_gemma":[0.994478,0.0007739039,0.002381369,0.00007407802,0.00001280373,0.0000821884,0.0006529733,0.000007252157,0.001537538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001100135,"threshold_uncertainty_score":0.003680289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03248264183008887,"score_gpt":0.3093950087782342,"score_spread":0.2769123669481453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}