{"id":"W4311302338","doi":"10.1016/j.breast.2022.12.003","title":"Final findings from the CONTROL trial: Strategies to reduce the incidence and severity of neratinib-associated diarrhea in patients with HER2-positive early-stage breast cancer","year":2022,"lang":"en","type":"article","venue":"The Breast","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; McGill University Health Centre","funders":"Puma Biotechnology","keywords":"Neratinib; Medicine; Loperamide; Diarrhea; Internal medicine; Incidence (geometry); Discontinuation; Gastroenterology; Tolerability; Oncology; Breast cancer; Adverse effect; Cancer; Trastuzumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001132771,0.0001686927,0.0003300048,0.00003959382,0.0003531114,0.00007339373,0.0003921915,0.00003678571,0.0003048498],"category_scores_gemma":[0.0001047045,0.00008493403,0.00004266069,0.0004897761,0.0003134097,0.00009887588,0.0002040837,0.0006789518,0.000002096559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000305522,"about_ca_system_score_gemma":0.0006124752,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04241964,"about_ca_topic_score_gemma":0.00369088,"domain_scores_codex":[0.997537,0.0007386308,0.0002573844,0.0002858708,0.0008385283,0.0003425998],"domain_scores_gemma":[0.9985495,0.0006562703,0.0001339436,0.000389054,0.0001840458,0.00008718208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05597825,0.0003917298,0.9280993,0.00001749907,0.0002309926,0.00002094886,0.01068729,0.0002839985,0.0002991151,0.00009301901,0.001293605,0.002604211],"study_design_scores_gemma":[0.0153114,0.0006800615,0.9814105,0.0001669899,0.0000620683,0.00001667295,0.001987876,0.0001033184,0.00006970992,0.00003542452,0.00005448698,0.0001014649],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802064,0.00008556712,0.000004400746,0.01494325,0.00008012036,0.001960415,0.002598559,0.00001481878,0.0001064398],"genre_scores_gemma":[0.9985713,0.00001134529,0.000005796434,0.0007075114,0.00008963183,0.0003890825,0.0000246592,0.00002395723,0.0001766773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05331118,"threshold_uncertainty_score":0.963957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02128492988764032,"score_gpt":0.3100970858514905,"score_spread":0.2888121559638502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}