{"id":"W4311303732","doi":"10.1093/braincomms/fcac314","title":"Polygenic coronary artery disease association with brain atrophy in the cognitively impaired","year":2022,"lang":"en","type":"article","venue":"Brain Communications","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; Centre hospitalier régional universitaire de Lille; H. Lundbeck A/S; Servier; University College London Hospitals NHS Foundation Trust; UCLH Biomedical Research Centre; Engineering and Physical Sciences Research Council; Institut National de la Santé et de la Recherche Médicale; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Agence Nationale de la Recherche; Alzheimer's Society; University of Southern California; Wellcome Trust; Roche; Novartis Pharmaceuticals Corporation; Eisai; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Université de Lille; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Medical Research Council; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Brain size; Dementia; Hyperintensity; Medicine; Context (archaeology); Alzheimer's Disease Neuroimaging Initiative; Neuroimaging; Atrophy; Disease; Internal medicine; Cardiology; White matter; Magnetic resonance imaging; Biology; Psychiatry; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00107708,0.0001068966,0.0001141085,0.00005121449,0.0005591911,0.00001744763,0.0007150887,0.00005412214,0.00002874686],"category_scores_gemma":[0.0005023619,0.00009298687,0.00007863028,0.0002431188,0.00008254708,0.000004066258,0.0003730918,0.0002387678,0.000007845252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009781992,"about_ca_system_score_gemma":0.0001886729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005652505,"about_ca_topic_score_gemma":0.0003122971,"domain_scores_codex":[0.9976372,0.001529623,0.000226839,0.0002099752,0.0001630621,0.0002333221],"domain_scores_gemma":[0.9981546,0.0006182573,0.0001739128,0.0009436903,0.00006061935,0.00004896794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000252885,0.0008966514,0.842785,0.000007016335,0.0002843502,0.00001158298,0.001379056,0.0009272624,0.007692818,0.001168656,0.1410205,0.003574249],"study_design_scores_gemma":[0.0007133139,0.0002510083,0.9232619,0.000003233449,0.00003014451,0.0000208871,0.001326961,0.0004789695,0.00000651545,0.0005648973,0.07318506,0.0001571122],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8980581,0.0009240767,0.0003249401,0.09889714,0.00004170127,0.000464766,0.0002186594,0.00001553611,0.001055065],"genre_scores_gemma":[0.9878613,0.00008160814,0.000555475,0.008937877,0.00005158769,0.0005108921,0.001187751,0.00001559821,0.0007979613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08995926,"threshold_uncertainty_score":0.4300902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0184931776279254,"score_gpt":0.2668790236527344,"score_spread":0.248385846024809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}