{"id":"W4311303732","doi":"10.1093/braincomms/fcac314","title":"Polygenic coronary artery disease association with brain atrophy in the cognitively impaired","year":2022,"lang":"en","type":"article","venue":"Brain Communications","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; Centre hospitalier régional universitaire de Lille; H. Lundbeck A/S; Servier; University College London Hospitals NHS Foundation Trust; UCLH Biomedical Research Centre; Engineering and Physical Sciences Research Council; Institut National de la Santé et de la Recherche Médicale; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Agence Nationale de la Recherche; Alzheimer's Society; University of Southern California; Wellcome Trust; Roche; Novartis Pharmaceuticals Corporation; Eisai; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Université de Lille; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Medical Research Council; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Brain size; Dementia; Hyperintensity; Medicine; Context (archaeology); Alzheimer's Disease Neuroimaging Initiative; Neuroimaging; Atrophy; Disease; Internal medicine; Cardiology; White matter; Magnetic resonance imaging; Biology; Psychiatry; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008869337,0.0003343898,0.0003709257,0.0009337635,0.000416943,0.0005321098,0.0003421378,0.0004307163,0.002396553],"category_scores_gemma":[0.002295873,0.0001882544,0.0005594898,0.0008658044,0.0004072987,0.0002097151,0.0005418714,0.0004320413,0.0001625743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001873819,"about_ca_system_score_gemma":0.0002395754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01339554,"about_ca_topic_score_gemma":0.01159528,"domain_scores_codex":[0.9994833,0.0002004129,0.00003756375,0.000149272,0.00005661288,0.00007281936],"domain_scores_gemma":[0.9985292,0.0005280349,0.0004164424,0.0002200396,0.000101861,0.0002043435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003866217,0.00007114756,0.9958326,0.000007987096,0.0002959809,0.0002113322,0.00008683237,0.000273037,0.001264557,0.00007136739,0.00009463105,0.001403963],"study_design_scores_gemma":[0.000005420859,0.00003648521,0.9991873,0.000001476384,0.00004256641,0.0001059571,0.0000239914,0.0004613266,0.00005123044,0.00005603633,0.00002608171,0.00000217345],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995379,0.00004456647,0.0001133722,0.00002033589,0.000001343411,0.000001979481,0.0001257366,0.000003459897,0.0001512871],"genre_scores_gemma":[0.9996654,0.00001713128,0.00008031914,0.000007276316,0.000002855447,0.000001777623,0.0001534952,0.00000123251,0.00007054926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01339554,"threshold_uncertainty_score":0.02663517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0184931776279254,"score_gpt":0.2668790236527344,"score_spread":0.248385846024809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}