{"id":"W4311305932","doi":"10.1038/s41467-022-35129-0","title":"Structure-function studies reveal ComEA contains an oligomerization domain essential for transformation in gram-positive bacteria","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"SLAC National Accelerator Laboratory; Basic Energy Sciences; Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Office of Science; Canada Foundation for Innovation; National Science Foundation; National Institutes of Health; U.S. Department of Health and Human Services; U.S. Department of Energy","keywords":"Bacillus subtilis; Peptidoglycan; Bacteria; Periplasmic space; DNA; Bacterial cell structure; Transformation (genetics); Gram-positive bacteria; Biology; DNA gyrase; Biophysics; Biochemistry; Gram-negative bacteria; Chemistry; Escherichia coli; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001354096,0.0003269007,0.0002292137,0.0001760404,0.0002125122,0.0002988102,0.0001303517,0.0004415645,0.00064179],"category_scores_gemma":[0.0002356437,0.0001637618,0.0003378932,0.0001496742,0.0002140961,0.0002765653,0.0001878469,0.000551941,0.0004093354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002588713,"about_ca_system_score_gemma":0.0001555958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000645584,"about_ca_topic_score_gemma":0.0008201094,"domain_scores_codex":[0.9999154,0.00001110047,0.000006425199,0.00001861265,0.00003537966,0.00001305901],"domain_scores_gemma":[0.9998354,0.00003086046,0.00003890217,0.00001137035,0.00001959669,0.00006392186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008498943,0.00004130843,0.001227692,0.00004585851,0.000007983444,0.0001395051,0.00003200579,0.0002576101,0.9967271,0.000191758,0.00004376304,0.001200508],"study_design_scores_gemma":[0.00002720376,0.000332855,0.0310032,0.00001349255,0.00002324809,0.001459638,0.00008419728,0.004536034,0.9578794,0.0002186431,0.004407641,0.00001440142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946951,0.001035047,0.00309731,0.0001285272,0.0000152346,0.000009564496,0.000168158,0.00008969949,0.0007613786],"genre_scores_gemma":[0.9947214,0.0004734154,0.003099125,0.00007238566,0.000007901118,0.000006124546,0.000839557,0.00001996343,0.0007601203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000645584,"threshold_uncertainty_score":0.002147019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01146801480170104,"score_gpt":0.2933282217334495,"score_spread":0.2818602069317484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}