{"id":"W4311309897","doi":"10.1016/j.celrep.2022.111822","title":"A specific type of Argonaute phosphorylation regulates binding to microRNAs during C. elegans development","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"H2020 Marie Skłodowska-Curie Actions; National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Novartis Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Deutsche Forschungsgemeinschaft","keywords":"Argonaute; microRNA; Phosphorylation; Biology; Gene silencing; Cell biology; Caenorhabditis elegans; Serine; Kinase; Genetics; RNA interference; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000212466,0.0001214818,0.0001258706,0.00006782572,0.0001701466,0.00001338334,0.0001084526,0.00004852668,0.00008763713],"category_scores_gemma":[0.00001401239,0.0001421589,0.00004736251,0.000129385,0.00001923419,0.000002008935,0.0002140599,0.00007075098,0.000006849767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004870068,"about_ca_system_score_gemma":0.0001044147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008350278,"about_ca_topic_score_gemma":0.000003654588,"domain_scores_codex":[0.9988967,0.00002288697,0.0003398201,0.0003543806,0.0001849184,0.0002013399],"domain_scores_gemma":[0.9993141,0.000002846153,0.000190117,0.000354121,0.00007044975,0.00006840294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002976196,0.00005121416,0.005508852,0.00002292777,0.00001651887,0.00003696758,0.0007208342,0.002257366,0.9903456,0.000001766645,0.000824439,0.0001837248],"study_design_scores_gemma":[0.0001005627,0.00007695309,0.01126836,0.000005550628,0.000007177337,0.00007732825,0.0001002663,0.000004204833,0.9297307,0.00001506198,0.05845296,0.000160873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997699,0.0006530526,0.0004087062,0.00002089965,0.0004380002,0.0001827217,0.000002689641,0.00001213183,0.0005827568],"genre_scores_gemma":[0.9925556,0.0000431581,0.003307406,0.00003297373,0.00006303845,0.00001239483,0.0001028313,0.00002839235,0.003854255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06061492,"threshold_uncertainty_score":0.5797071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128170306318727,"score_gpt":0.2129556222233473,"score_spread":0.2016739191601601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}