{"id":"W4311325417","doi":"10.3389/fimmu.2022.1060957","title":"Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU)","year":2022,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"Canadian Cancer Society Research Institute; Terry Fox Research Institute; Pancreatic Cancer Canada Foundation; PanKind, The Australian Pancreatic Cancer Foundation; University of New South Wales; Government of Ontario; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation","keywords":"Cancer research; Downregulation and upregulation; Stromal cell; Tumor microenvironment; Urokinase receptor; Metastasis; Pancreatic cancer; Epithelial–mesenchymal transition; Biology; Cancer; Medicine; Plasminogen activator; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001475292,0.0002210888,0.0003239939,0.0004637062,0.0001588898,0.0005929958,0.0000738254,0.0001519829,0.0004929293],"category_scores_gemma":[0.0002340211,0.00008681929,0.0002265654,0.0006775383,0.0002103605,0.0001321422,0.0002105018,0.0002695555,0.0001174542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002117478,"about_ca_system_score_gemma":0.0002220265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003647396,"about_ca_topic_score_gemma":0.0003883005,"domain_scores_codex":[0.9998677,0.00002527979,0.00001109269,0.00004055332,0.00003283362,0.00002266331],"domain_scores_gemma":[0.9998314,0.00003380919,0.00007785335,0.00001206614,0.00001429397,0.00003047563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001021933,0.00006139223,0.07805767,0.0003007408,0.00008322052,0.0007673711,0.0001068814,0.0009591105,0.8979152,0.0002152282,0.0001453973,0.02036588],"study_design_scores_gemma":[0.00003118549,0.0006337959,0.6166725,0.00003509965,0.00020985,0.004913956,0.0003410335,0.008494033,0.3634697,0.0006814899,0.004486643,0.00003075771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933839,0.003075948,0.002429605,0.00005723846,0.000005831923,0.00001505329,0.0005877667,0.00005862714,0.0003860149],"genre_scores_gemma":[0.9966171,0.0009451139,0.00180828,0.00002554574,0.000007534034,0.00001630216,0.0003908263,0.000005663017,0.0001836496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005929958,"threshold_uncertainty_score":0.001649022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00926551340820071,"score_gpt":0.2375459022542638,"score_spread":0.2282803888460631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}