{"id":"W4311325978","doi":"10.21203/rs.3.rs-2306141/v1","title":"Multivalent Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccines Demonstrate a Greater Breadth in T cell but not Antibody Responses","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Center for Advancing Translational Sciences; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Johns Hopkins University; Sanofi; Welch Foundation","keywords":"Virology; Glycoprotein; Antibody; Nucleoside; Human cytomegalovirus; Cytomegalovirus; Messenger RNA; Chemistry; Biology; Virus; Molecular biology; Immunology; Gene; Herpesviridae; Biochemistry; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001977721,0.0004489398,0.0002863153,0.0002045871,0.000112077,0.0003768642,0.0001361695,0.0004677563,0.003471677],"category_scores_gemma":[0.000226816,0.0001347957,0.0001813598,0.00012973,0.0001893412,0.0002554169,0.0002294875,0.0009130973,0.00066153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002206869,"about_ca_system_score_gemma":0.0001411029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003116481,"about_ca_topic_score_gemma":0.0003872562,"domain_scores_codex":[0.9998548,0.0000229315,0.000007472453,0.00003907795,0.00002830842,0.00004732181],"domain_scores_gemma":[0.9998704,0.000056853,0.00001919319,0.0000163131,0.00001332332,0.00002386274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001166768,0.00003346048,0.00006420354,0.00002000636,0.000004199893,0.00001230769,0.000009463865,0.00006214304,0.9974321,0.0001054511,0.00005635033,0.002083816],"study_design_scores_gemma":[0.00007359379,0.001325399,0.002228307,0.000008394039,0.00004179075,0.0002603904,0.0000354497,0.0007771152,0.9917049,0.0001725287,0.003367437,0.000004655362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899123,0.001325402,0.003958231,0.0001422015,0.0001117136,0.00005746907,0.000180777,0.0001233773,0.004188497],"genre_scores_gemma":[0.9937483,0.0005326711,0.001980351,0.0001226773,0.00004979107,0.0000323552,0.0002881649,0.00004568811,0.003200018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003471677,"threshold_uncertainty_score":0.01161391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1035693385571204,"score_gpt":0.4305903508988376,"score_spread":0.3270210123417172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}