{"id":"W4311328513","doi":"10.1016/j.carbpol.2022.120454","title":"A novel sulfated mannan-carboxymethyl-5-fluorouracil-folic acid conjugates for targeted anticancer drug delivery","year":2022,"lang":"en","type":"article","venue":"Carbohydrate Polymers","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Research Foundation of Korea; Ministry of Education","keywords":"Chemistry; Targeted drug delivery; In vitro; Drug delivery; Pharmacology; Drug; Folate receptor; Fluorouracil; Sulfation; Conjugate; Biochemistry; Drug carrier; In vivo; Chemotherapy; Cancer cell; Cancer; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001013957,0.0003478245,0.0001740179,0.0001786734,0.0001960635,0.0002601726,0.000232462,0.0004283679,0.0008759066],"category_scores_gemma":[0.0001193863,0.000137129,0.0001710001,0.0001786073,0.0001101563,0.0002541057,0.0002020358,0.0003576107,0.0002829306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003683766,"about_ca_system_score_gemma":0.0002534532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001114163,"about_ca_topic_score_gemma":0.001383243,"domain_scores_codex":[0.9999307,0.00001336333,0.000004261488,0.00001415357,0.00001746838,0.00001986858],"domain_scores_gemma":[0.9999622,0.000004311318,0.00001123351,0.000002670553,0.000006020768,0.00001357484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001446638,0.00003755055,0.0001146224,0.00007291947,0.000013113,0.0001597094,0.00002571169,0.000311355,0.9885653,0.0004855795,0.0001975844,0.00987198],"study_design_scores_gemma":[0.00002638819,0.0006408967,0.0008445642,0.000008217968,0.00003489345,0.0003692743,0.000009684998,0.001611018,0.9863186,0.00004014159,0.01008218,0.00001416763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692358,0.005975373,0.01647683,0.0003527235,0.0001284864,0.0001420331,0.0001805308,0.0001746499,0.007333579],"genre_scores_gemma":[0.9833278,0.001864243,0.00928926,0.0001129931,0.00002132715,0.000057389,0.0001225507,0.00001304186,0.005191361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001114163,"threshold_uncertainty_score":0.002930224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02377763820546549,"score_gpt":0.2836223953782261,"score_spread":0.2598447571727606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}