{"id":"W4311363784","doi":"10.1002/cjce.24811","title":"Investigation of the <scp>candesartan cilexetil</scp> antihypertensive drug microencapsulation by <scp>PLA‐PVP K30</scp> biodegradable polymers: Experimental optimization and release kinetics modelling","year":2022,"lang":"en","type":"article","venue":"The Canadian Journal of Chemical Engineering","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Candesartan; Bioavailability; Chemistry; Controlled release; Solubility; PLGA; Chromatography; Maltodextrin; Polymer; Nuclear chemistry; Biodegradable polymer; Pharmacology; Materials science; Spray drying; Organic chemistry; Angiotensin II; Nanotechnology; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004243447,0.0001640828,0.000228946,0.0001133129,0.0002868242,0.00003570203,0.0002742277,0.000110773,0.00002493971],"category_scores_gemma":[0.0001369755,0.0001364442,0.00008773575,0.0002689404,0.00017816,0.0001226242,0.00004496723,0.0006665481,5.10541e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001883229,"about_ca_system_score_gemma":0.0002075733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008511402,"about_ca_topic_score_gemma":0.00002038059,"domain_scores_codex":[0.9987407,0.0001700252,0.0004297491,0.0001340174,0.0002223612,0.000303108],"domain_scores_gemma":[0.9987816,0.0003258983,0.0002936064,0.0001225756,0.0001273526,0.0003489961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005152698,0.0000147772,0.0004239034,0.00002278492,0.00006219177,0.000006169197,0.002436109,0.6066328,0.3867425,0.00005320664,0.003572433,0.00002798431],"study_design_scores_gemma":[0.0004677942,0.00003871702,0.00001875105,0.00003208568,0.00007408517,0.0001036505,0.0007647955,0.4270358,0.5676896,0.00002658657,0.003710253,0.00003789749],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934117,0.004726056,0.0005602903,0.0003852675,0.0005811396,0.0001823819,0.00007334162,0.00001063126,0.00006916803],"genre_scores_gemma":[0.9989753,0.00002937038,0.0002257349,0.0004862446,0.0001153482,0.000006153855,0.00001825869,0.00002246707,0.0001211292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1809471,"threshold_uncertainty_score":0.5564033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03449031341654463,"score_gpt":0.2517430093110113,"score_spread":0.2172526958944667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}