{"id":"W4311363784","doi":"10.1002/cjce.24811","title":"Investigation of the <scp>candesartan cilexetil</scp> antihypertensive drug microencapsulation by <scp>PLA‐PVP K30</scp> biodegradable polymers: Experimental optimization and release kinetics modelling","year":2022,"lang":"en","type":"article","venue":"The Canadian Journal of Chemical Engineering","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Candesartan; Bioavailability; Chemistry; Controlled release; Solubility; PLGA; Chromatography; Maltodextrin; Polymer; Nuclear chemistry; Biodegradable polymer; Pharmacology; Materials science; Spray drying; Organic chemistry; Angiotensin II; Nanotechnology; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004237355,0.0003185491,0.0002903584,0.0001752905,0.0001194786,0.0003281398,0.0001699967,0.0002899123,0.0004452736],"category_scores_gemma":[0.0003650116,0.0001533751,0.0004260035,0.000189252,0.0001888711,0.0002210083,0.0001111821,0.0002472869,0.0001856271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000314818,"about_ca_system_score_gemma":0.0002683477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001328739,"about_ca_topic_score_gemma":0.001051045,"domain_scores_codex":[0.9998069,0.00002901449,0.00001633702,0.0000437029,0.00008227222,0.00002184757],"domain_scores_gemma":[0.9997784,0.00009349901,0.00007136457,0.00001523677,0.00003016319,0.00001130503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001305893,0.00005428575,0.0003475511,0.0001682077,0.00001603904,0.0000676472,0.0000227666,0.007428203,0.9870689,0.0001039759,0.00004015972,0.004551723],"study_design_scores_gemma":[0.00001146398,0.0005104432,0.001387156,0.000006449198,0.00002670249,0.00004463249,0.00001127836,0.04167665,0.9555968,0.00002136794,0.000697027,0.00001005376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876609,0.0007136532,0.0104626,0.00002820314,0.00001247298,0.0000463883,0.0002061098,0.000063901,0.0008056713],"genre_scores_gemma":[0.9899126,0.0007471174,0.008453144,0.000007192516,0.000003799817,0.00005733715,0.00009602395,0.00001986967,0.0007030256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001328739,"threshold_uncertainty_score":0.002642035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03449031341654463,"score_gpt":0.2517430093110113,"score_spread":0.2172526958944667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}