{"id":"W4311367297","doi":"10.1080/17460441.2022.2155630","title":"A comprehensive update of siRNA delivery design strategies for targeted and effective gene silencing in gene therapy and other applications","year":2022,"lang":"en","type":"review","venue":"Expert Opinion on Drug Discovery","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Gene silencing; Genetic enhancement; Computational biology; Gene; RNA interference; Biology; Gene targeting; Gene delivery; Genetics; Bioinformatics; Medicine; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004966437,0.0009320532,0.0009859604,0.001798964,0.0002630138,0.0007836531,0.0007470053,0.0009554601,0.006306955],"category_scores_gemma":[0.0004933832,0.0003491288,0.0005511338,0.001725986,0.0002640946,0.001056896,0.0004727638,0.001629745,0.004190776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000561284,"about_ca_system_score_gemma":0.000732606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008965749,"about_ca_topic_score_gemma":0.001632314,"domain_scores_codex":[0.9997986,0.00002962052,0.00002896898,0.00003353763,0.00008610355,0.00002327712],"domain_scores_gemma":[0.999797,0.00007996879,0.00002760884,0.000006729711,0.00007261783,0.00001599533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006984346,0.00009317654,0.00008181164,0.02336206,0.00007647926,0.0002738086,0.00007598533,0.0005360081,0.0138694,0.003940434,0.05944873,0.8981723],"study_design_scores_gemma":[0.000008182221,0.00008660361,0.0002006301,0.001200993,0.00006468446,0.0006461636,0.00001633937,0.0001047272,0.001943101,0.0005531499,0.9951612,0.0000142316],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002985389,0.9943268,0.0009249084,0.0003577455,0.0006548502,0.0000227297,0.00008551741,0.00002748729,0.003301477],"genre_scores_gemma":[0.001072183,0.9944072,0.0008979937,0.00035659,0.0002284423,0.00002819158,0.0001511519,0.00000736793,0.002850982],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006306955,"threshold_uncertainty_score":0.02109885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05998662120675698,"score_gpt":0.337684041426251,"score_spread":0.277697420219494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}