{"id":"W4311393649","doi":"10.1089/hum.2022.079","title":"Genome Editing of <i>Pik3cd</i> Impedes Abnormal Retinal Angiogenesis","year":2022,"lang":"fa","type":"article","venue":"Human Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Angiogenesis; Retinal; Biology; Molecular biology; Cell biology; Cancer research; Chemistry; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001544831,0.0002684278,0.0002511427,0.0001594215,0.0001488991,0.0003571238,0.000257922,0.000316637,0.001449967],"category_scores_gemma":[0.0001491665,0.0001332939,0.0002898382,0.0001141983,0.0002401412,0.0001335937,0.0002121844,0.0006575277,0.0003188313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003324902,"about_ca_system_score_gemma":0.000260281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001552236,"about_ca_topic_score_gemma":0.001731213,"domain_scores_codex":[0.9998024,0.00002090824,0.00002651492,0.00005380566,0.00005530465,0.00004117872],"domain_scores_gemma":[0.9998921,0.00001728996,0.00004073214,0.0000133994,0.000007967133,0.00002837773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008301334,0.00001888267,0.0001208105,0.00002731989,0.0000103532,0.00006173977,0.00001014081,0.0001251326,0.9973247,0.0003128317,0.0001306215,0.001774514],"study_design_scores_gemma":[0.00002984625,0.0001725153,0.002432304,0.000008180492,0.00003358367,0.0004655815,0.00002033537,0.003062191,0.9852416,0.0001160502,0.008408447,0.000009426192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763002,0.0007324468,0.01590996,0.0002899562,0.0001170597,0.00007789565,0.001043551,0.0007972863,0.004731504],"genre_scores_gemma":[0.9920982,0.0003387684,0.004197264,0.0001214966,0.0000105419,0.00003765026,0.0004463047,0.00009117035,0.002658689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001552236,"threshold_uncertainty_score":0.004850626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01197461777047956,"score_gpt":0.2801332500295328,"score_spread":0.2681586322590532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}