{"id":"W4311393649","doi":"10.1089/hum.2022.079","title":"Genome Editing of <i>Pik3cd</i> Impedes Abnormal Retinal Angiogenesis","year":2022,"lang":"fa","type":"article","venue":"Human Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Angiogenesis; Retinal; Biology; Molecular biology; Cell biology; Cancer research; Chemistry; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005018276,0.0003678536,0.0003714154,0.0001230463,0.0005101737,0.00002911316,0.0005426802,0.0001337933,0.001005006],"category_scores_gemma":[0.000008117789,0.0004345128,0.0003758826,0.0002032441,0.0001200321,0.000004381953,0.00038201,0.0002036897,0.000005163702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004414181,"about_ca_system_score_gemma":0.0000969785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005217444,"about_ca_topic_score_gemma":0.00001033741,"domain_scores_codex":[0.9977962,0.0001618771,0.0005535918,0.0005560455,0.000358389,0.0005739278],"domain_scores_gemma":[0.9988714,0.00001328682,0.00024797,0.0006446704,0.00009407406,0.0001286033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001583967,0.0001562585,0.001890244,0.00004784597,0.0002530235,0.00001851085,0.0006527312,0.003682776,0.9903134,0.00003284846,0.0003999599,0.002393985],"study_design_scores_gemma":[0.001425556,0.001921427,0.01178149,0.00001108471,0.00006269979,0.000124491,0.0006685239,0.00005698664,0.9207507,0.00003582418,0.06259511,0.0005661579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9602901,0.03694232,0.0008497984,0.00006659711,0.0004581283,0.0002922628,0.000218476,0.00002291429,0.0008593388],"genre_scores_gemma":[0.9943206,0.002099848,0.000458612,0.0001669893,0.001547978,0.00006216608,0.0004184341,0.0000938364,0.0008315565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06956276,"threshold_uncertainty_score":0.9999082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01197461777047956,"score_gpt":0.2801332500295328,"score_spread":0.2681586322590532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}