{"id":"W4311436859","doi":"10.1038/s41586-022-05534-y","title":"Microglia regulate central nervous system myelin growth and integrity","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":475,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto East General Hospital; Public Health Ontario; University of Toronto; St. Michael's Hospital","funders":"Medical Research Council; Reta Lila Weston Institute of Neurological Studies, UCL Queen Square Institute of Neurology,University College London; Directorate for Biological Sciences; Fondation Charcot; Simons Initiative for the Developing Brain; UK Dementia Research Institute; Vlaamse regering; University of Edinburgh; Wellcome Trust; Multiple Sclerosis Society; Fonds Wetenschappelijk Onderzoek; University College London","keywords":"Myelin; Microglia; Central nervous system; Oligodendrocyte; Neuroscience; Biology; Macrophage; Neuroinflammation; Cell biology; Immunology; Inflammation; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001263909,0.0001267939,0.0001160948,0.00008356783,0.0004581663,0.00007720969,0.0002179167,0.0001909509,0.00007864883],"category_scores_gemma":[0.0001503863,0.000121289,0.00004438217,0.000253746,0.00002862757,0.0001074931,0.0001575563,0.002107808,0.00001204269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004178027,"about_ca_system_score_gemma":0.0000331555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003268207,"about_ca_topic_score_gemma":0.000001577744,"domain_scores_codex":[0.9985294,0.0003033649,0.0001726014,0.000417407,0.0003518082,0.0002254562],"domain_scores_gemma":[0.9995487,0.0000554564,0.0000841041,0.0001928688,0.00002305978,0.00009581884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002948718,0.00001483516,0.000029035,0.00002414441,8.70555e-7,0.00007895195,0.0000993528,0.00003378367,0.9192281,0.07816842,0.001909039,0.0003839462],"study_design_scores_gemma":[0.0003159121,0.00005781644,0.0006094589,0.000005016928,0.000005993734,0.0003770831,0.00007032364,0.002598358,0.9875539,0.0004018967,0.007860214,0.0001440229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937505,0.00008831119,0.0000891923,0.003026699,0.001626616,0.0002635956,0.00006914917,0.0002757139,0.0008102723],"genre_scores_gemma":[0.9945337,0.00001636886,0.0001567044,0.004274843,0.0001130392,0.0000161197,0.000006608535,0.0000189623,0.0008636462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07776653,"threshold_uncertainty_score":0.9157495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01318996628922534,"score_gpt":0.2315825302047592,"score_spread":0.2183925639155339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}