{"id":"W4311436859","doi":"10.1038/s41586-022-05534-y","title":"Microglia regulate central nervous system myelin growth and integrity","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":475,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto East General Hospital; Public Health Ontario; University of Toronto; St. Michael's Hospital","funders":"Medical Research Council; Reta Lila Weston Institute of Neurological Studies, UCL Queen Square Institute of Neurology,University College London; Directorate for Biological Sciences; Fondation Charcot; Simons Initiative for the Developing Brain; UK Dementia Research Institute; Vlaamse regering; University of Edinburgh; Wellcome Trust; Multiple Sclerosis Society; Fonds Wetenschappelijk Onderzoek; University College London","keywords":"Myelin; Microglia; Central nervous system; Oligodendrocyte; Neuroscience; Biology; Macrophage; Neuroinflammation; Cell biology; Immunology; Inflammation; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000190283,0.000400722,0.0001919098,0.0002570006,0.0001912764,0.0003527021,0.0001640745,0.0002559308,0.0008884502],"category_scores_gemma":[0.0001121556,0.00007791708,0.0001535363,0.0001031753,0.000312781,0.0001936097,0.0002756289,0.000425736,0.0003969561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002735617,"about_ca_system_score_gemma":0.0002074716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005487697,"about_ca_topic_score_gemma":0.00069871,"domain_scores_codex":[0.999876,0.00002689944,0.000006555766,0.00001759343,0.00003994466,0.00003299131],"domain_scores_gemma":[0.9998657,0.00001110795,0.00005921928,0.000007755776,0.00003057664,0.00002560316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001976183,0.00001837576,0.0007088067,0.0001461177,0.000008650153,0.0002489344,0.00004747219,0.00009339217,0.9916681,0.0004884488,0.0002140067,0.006160008],"study_design_scores_gemma":[0.00005458354,0.0007384036,0.04638789,0.0001991126,0.00009830342,0.002342079,0.0003707946,0.001550063,0.9233512,0.002894187,0.0219939,0.0000194777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.898682,0.08281071,0.007449545,0.0008540241,0.0001904851,0.00004162957,0.0004842958,0.0002549568,0.009232314],"genre_scores_gemma":[0.9776906,0.01526998,0.00208263,0.0001565387,0.00007808518,0.00002383249,0.000121595,0.00002440602,0.004552304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008884502,"threshold_uncertainty_score":0.002972126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01318996628922534,"score_gpt":0.2315825302047592,"score_spread":0.2183925639155339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}