{"id":"W4311441345","doi":"10.1101/2022.12.11.520005","title":"Absence of the bile acid enzyme CYP8B1 increases brain chenodeoxycholic acid and reduces neuronal excitotoxicity in mice","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Memorial University of Newfoundland","funders":"","keywords":"Excitotoxicity; Glutamate receptor; Chenodeoxycholic acid; NMDA receptor; Chemistry; CYP8B1; Endocrinology; Internal medicine; Biology; Cell biology; Biochemistry; Bile acid; Medicine; Receptor; Cholic acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002466711,0.0008147485,0.0007876013,0.001008877,0.0002973177,0.0005891161,0.0004307152,0.0008149411,0.002709452],"category_scores_gemma":[0.0002355107,0.0005105588,0.0004718528,0.0003935296,0.0006669034,0.0004462275,0.0002777551,0.001762449,0.0007756822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006098976,"about_ca_system_score_gemma":0.0003945414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001005951,"about_ca_topic_score_gemma":0.001557484,"domain_scores_codex":[0.9995654,0.00004927726,0.00006550397,0.0001209078,0.00009054137,0.0001082469],"domain_scores_gemma":[0.9993908,0.00003722006,0.0002208479,0.00006265716,0.00006475483,0.0002235682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001140572,0.0001778427,0.0003377894,0.00006823511,0.00002820233,0.00004242297,0.00002158347,0.00005308726,0.9966667,0.0001077456,0.0001202423,0.001235519],"study_design_scores_gemma":[0.0001796072,0.001400326,0.005040579,0.00002560614,0.00008188965,0.0001981381,0.00005867865,0.0005629903,0.9896459,0.0001286482,0.002664925,0.00001271349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887311,0.002311512,0.003582787,0.0006711038,0.0001237716,0.00009290056,0.002565881,0.0005027946,0.001418118],"genre_scores_gemma":[0.9815726,0.002242774,0.004468137,0.0002875602,0.00004382451,0.0003050007,0.002443322,0.0002098617,0.008426806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002709452,"threshold_uncertainty_score":0.009064019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01239353301667986,"score_gpt":0.2262750003038044,"score_spread":0.2138814672871245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}