{"id":"W4311449820","doi":"10.1021/acs.molpharmaceut.2c00815","title":"Treatment of Orthotopic U251 Human Glioblastoma Multiforme Tumors in NRG Mice by Convection-Enhanced Delivery of Gold Nanoparticles Labeled with the β-Particle-Emitting Radionuclide, <sup>177</sup>Lu","year":2022,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; Hospital for Sick Children; University of Toronto","funders":"Terry Fox Foundation; Natural Sciences and Engineering Research Council of Canada; Brain Tumour Foundation of Canada; University of Toronto; Canadian Cancer Society","keywords":"Clonogenic assay; Biodistribution; Colloidal gold; Chemistry; Nuclear medicine; Radionuclide therapy; Cancer research; Brain tumor; Glioma; Medicine; Pathology; In vitro; Materials science; Nanoparticle; Nanotechnology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001803159,0.0002241277,0.0003831976,0.00004542688,0.0001709752,0.000009547401,0.0001736067,0.00004603247,0.00008990633],"category_scores_gemma":[0.00001961253,0.0001800148,0.0001182766,0.0006356199,0.0002261792,0.00004728917,0.00005716227,0.0002812839,0.00000232503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001911823,"about_ca_system_score_gemma":0.00008750409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004769586,"about_ca_topic_score_gemma":0.000003678323,"domain_scores_codex":[0.998299,0.0001302426,0.0005243259,0.0003189104,0.0003760036,0.0003514964],"domain_scores_gemma":[0.9990858,0.0001289065,0.0002192266,0.0003161613,0.00009706051,0.0001528626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005124224,0.001041517,0.003477592,0.0001160315,0.0001641128,0.00006398474,0.0007127817,0.004497404,0.9881548,0.00009532567,0.00004496304,0.001119027],"study_design_scores_gemma":[0.005079853,0.0005860449,0.0002138473,0.00003288929,0.0003141876,0.00008537488,0.001087721,0.01998684,0.9700033,0.000007280822,0.002440462,0.0001622195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997435,0.0007327436,0.00006144092,0.0006712287,0.00001173069,0.000807847,0.00004523657,0.0000427237,0.0001920474],"genre_scores_gemma":[0.9989193,0.00005971978,0.0001763206,0.0002919507,0.00002153207,0.0002762486,0.0000288169,0.00003447861,0.0001916519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01815156,"threshold_uncertainty_score":0.7340792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01658515178659952,"score_gpt":0.2983626271436008,"score_spread":0.2817774753570013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}