{"id":"W4311449820","doi":"10.1021/acs.molpharmaceut.2c00815","title":"Treatment of Orthotopic U251 Human Glioblastoma Multiforme Tumors in NRG Mice by Convection-Enhanced Delivery of Gold Nanoparticles Labeled with the β-Particle-Emitting Radionuclide, <sup>177</sup>Lu","year":2022,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; Hospital for Sick Children; University of Toronto","funders":"Terry Fox Foundation; Natural Sciences and Engineering Research Council of Canada; Brain Tumour Foundation of Canada; University of Toronto; Canadian Cancer Society","keywords":"Clonogenic assay; Biodistribution; Colloidal gold; Chemistry; Nuclear medicine; Radionuclide therapy; Cancer research; Brain tumor; Glioma; Medicine; Pathology; In vitro; Materials science; Nanoparticle; Nanotechnology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001755746,0.0004030429,0.0003071197,0.000146338,0.00008459546,0.0001371422,0.0001577932,0.0002353078,0.0002848952],"category_scores_gemma":[0.00006131371,0.0001111087,0.0002332815,0.00007187664,0.0002184007,0.0001527408,0.00007757686,0.0002814668,0.00008994509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002464668,"about_ca_system_score_gemma":0.0001784198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0015156,"about_ca_topic_score_gemma":0.001989556,"domain_scores_codex":[0.9999242,0.00001216484,0.000004468805,0.00002134515,0.00001802724,0.00001994669],"domain_scores_gemma":[0.9999595,0.000006788863,0.00001452273,0.000004882165,0.00000482767,0.000009526706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006183884,0.00002486437,0.00007090893,0.00001789597,0.000003372185,0.00001688058,0.00001303508,0.00009938819,0.998726,0.00002043558,0.00001968236,0.0009259074],"study_design_scores_gemma":[0.00001854402,0.0009022435,0.001419826,0.0000020148,0.00001453767,0.0001057403,0.00001187442,0.0007186582,0.9959282,0.00001429957,0.0008606939,0.000003295499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950725,0.001428456,0.002671667,0.00008878847,0.00002455968,0.00005254846,0.0001143515,0.00008731004,0.0004596576],"genre_scores_gemma":[0.9912905,0.0009573227,0.006211983,0.00006578939,0.000009573628,0.00004971892,0.0001325883,0.00002235636,0.001260142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0015156,"threshold_uncertainty_score":0.003013611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01658515178659952,"score_gpt":0.2983626271436008,"score_spread":0.2817774753570013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}