{"id":"W4311451928","doi":"10.1021/acs.biochem.2c00393","title":"Structural Determinants and Functional Significance of Dimerization for Osmosensing Transporter ProP in <i>Escherichia coli</i>","year":2022,"lang":"en","type":"article","venue":"Biochemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Coiled coil; Transmembrane domain; Chemistry; Escherichia coli; Antiparallel (mathematics); Biophysics; Biochemistry; Dimer; Transmembrane protein; Periplasmic space; Cysteine; Monomer; Amino acid; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009486839,0.0001796824,0.0001467592,0.00009535261,0.0001679782,0.0002593824,0.0001793701,0.0002304735,0.0006642023],"category_scores_gemma":[0.0001548828,0.0001333078,0.000181577,0.000111021,0.0002398311,0.0001315847,0.0001742332,0.0004082528,0.0003598001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000422609,"about_ca_system_score_gemma":0.0001435513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006759936,"about_ca_topic_score_gemma":0.0006147142,"domain_scores_codex":[0.9999037,0.00002617554,0.000009228404,0.00001974739,0.00002041491,0.0000208542],"domain_scores_gemma":[0.9998562,0.00002256314,0.0000422946,0.00001108765,0.00001815058,0.00004970327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001173262,0.00001832537,0.0004801764,0.00001431441,0.00000321959,0.000060713,0.00001327985,0.00009023309,0.9988104,0.00009474481,0.00002795773,0.0002693554],"study_design_scores_gemma":[0.00002473423,0.0001224331,0.01608553,0.00001008779,0.00001615256,0.0004814887,0.00009114366,0.003921665,0.97798,0.00008085338,0.001174209,0.00001166928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998594,0.0001341157,0.0007833079,0.00005877886,0.000004581793,0.000006678725,0.0001031002,0.00001467365,0.0003007987],"genre_scores_gemma":[0.9982669,0.00007303058,0.000743802,0.00006042081,0.000003504067,0.000009602182,0.0003934067,0.00001147215,0.0004377766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006759936,"threshold_uncertainty_score":0.003066301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01090210085972271,"score_gpt":0.2308741817885123,"score_spread":0.2199720809287896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}