{"id":"W4311452644","doi":"10.1101/2022.12.13.22282475","title":"Genome-wide association study of multiple neuropathology endophenotypes identifies novel risk loci and provides insights into known Alzheimer’s risk loci","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Pennsylvania; University of Southern California; Illinois Department of Public Health; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Neuropathology; Cerebral amyloid angiopathy; Senile plaques; Genome-wide association study; Endophenotype; Alzheimer's disease; Neuroscience; Apolipoprotein E; Pathology; Biology; Dementia; Disease; Medicine; Genetics; Single-nucleotide polymorphism; Genotype; Gene; Cognition","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002153796,0.0006489711,0.0005954138,0.001892691,0.000561066,0.0008199203,0.0005793778,0.0005285615,0.002648161],"category_scores_gemma":[0.003250642,0.0002648439,0.001374424,0.002400286,0.0004384412,0.00024716,0.0009620031,0.0006538327,0.0001945334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002903689,"about_ca_system_score_gemma":0.0004203844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004046489,"about_ca_topic_score_gemma":0.006554139,"domain_scores_codex":[0.9982989,0.0006445458,0.0001435679,0.0006127481,0.0001691999,0.0001310017],"domain_scores_gemma":[0.996691,0.001488304,0.0009819776,0.0004140117,0.0002129957,0.0002116286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006107947,0.00006861689,0.9776902,0.00006046232,0.002314494,0.0006267813,0.0001393237,0.0007807036,0.008310234,0.0004188468,0.0002611085,0.008718523],"study_design_scores_gemma":[0.00006395564,0.00008417634,0.9930977,0.00002052721,0.0009055731,0.0006430362,0.0001022595,0.002296173,0.00102785,0.001193527,0.0005500877,0.00001505241],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928336,0.0006948828,0.004661311,0.0001485501,0.00001332676,0.00001934939,0.0009292722,0.00003993858,0.0006596717],"genre_scores_gemma":[0.9963966,0.0001769516,0.002566038,0.00004878286,0.00001531878,0.00002251479,0.0005803745,0.000009433633,0.00018409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004046489,"threshold_uncertainty_score":0.01139051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03443955121509291,"score_gpt":0.301544117934643,"score_spread":0.2671045667195501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}