{"id":"W4311458224","doi":"10.1371/journal.pone.0277668","title":"Scalable agroinfiltration-based production of SARS-CoV-2 antigens for use in diagnostic assays and subunit vaccines","year":2022,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"National Research Council Canada; Agriculture and Agri-Food Canada; University of Cape Town; Canadian Institutes of Health Research; University of Ottawa","keywords":"Agroinfiltration; Antigen; Virology; Protein subunit; Antibody; Biology; Epitope; Recombinant DNA; Computational biology; Virus; Biochemistry; Immunology; Nicotiana benthamiana; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002444485,0.0003835694,0.000281492,0.0002502075,0.0001376577,0.0003230423,0.0002187099,0.0003529547,0.0005483287],"category_scores_gemma":[0.0001335512,0.000141795,0.0003101672,0.000261619,0.0002000451,0.0002413025,0.0002957388,0.0007981585,0.0002983397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003610221,"about_ca_system_score_gemma":0.0002306872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003704816,"about_ca_topic_score_gemma":0.000645361,"domain_scores_codex":[0.999844,0.00002037036,0.00001234081,0.00003785313,0.00006526087,0.00002006957],"domain_scores_gemma":[0.9999266,0.00001172238,0.00002572955,0.00001171679,0.00001066391,0.00001365483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008909261,0.000007055411,0.00002628345,0.00001209714,0.000001149867,0.00001439581,0.000003454352,0.0000412486,0.9994572,0.00003188302,0.00001320352,0.0003831153],"study_design_scores_gemma":[0.000009469263,0.0001431274,0.0009889008,0.000004639858,0.000008263532,0.0001540297,0.00001437311,0.001469385,0.9949229,0.00008049342,0.002198542,0.000005743908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8966228,0.002487997,0.09454026,0.0003602626,0.0001125166,0.000299434,0.002044839,0.0006433527,0.002888443],"genre_scores_gemma":[0.9377291,0.001664425,0.05553029,0.0001120848,0.00001560433,0.0001110819,0.002500178,0.00006529232,0.00227183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005483287,"threshold_uncertainty_score":0.002619445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05366817330877501,"score_gpt":0.2532912448715267,"score_spread":0.1996230715627517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}