{"id":"W4311461758","doi":"10.1002/alz.12875","title":"Tau‐PET is superior to phospho‐tau when predicting cognitive decline in symptomatic AD patients","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; Parkinsonfonden; National Institutes of Health; UK Dementia Research Institute; IXICO; H. Lundbeck A/S; Genentech; Marcus och Amalia Wallenbergs minnesfond; Skånes universitetssjukhus; European Commission; Familjen Erling-Perssons Stiftelse; Hjärnfonden; Vetenskapsrådet; Eisai; EU Joint Programme – Neurodegenerative Disease Research; European Research Council; Northern California Institute for Research and Education; Servier; Knut och Alice Wallenbergs Stiftelse; Pfizer; Biogen; BioClinica; University of Southern California; Lunds Universitet; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Australian Government; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Drug Discovery Foundation","keywords":"Cognitive decline; Cognition; Neuroimaging; Dementia; Alzheimer's Disease Neuroimaging Initiative; Internal medicine; Magnetic resonance imaging; Positron emission tomography; Psychology; Apolipoprotein E; Atrophy; Medicine; Effects of sleep deprivation on cognitive performance; Pittsburgh compound B; Disease; Neuroscience; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007860149,0.00114489,0.001543316,0.0005567268,0.0003814584,0.001468925,0.0005321182,0.001256751,0.001449505],"category_scores_gemma":[0.01081119,0.000378687,0.001207543,0.0002921843,0.0003950512,0.001324915,0.0003976384,0.0007469687,0.0004833277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003360549,"about_ca_system_score_gemma":0.0005577573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006300528,"about_ca_topic_score_gemma":0.001388847,"domain_scores_codex":[0.9984805,0.0008881248,0.000130204,0.0003022396,0.000126643,0.0000723284],"domain_scores_gemma":[0.9960471,0.002541571,0.0003600299,0.0002758784,0.0003488009,0.0004265743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1058364,0.002226925,0.7865252,0.0003953111,0.002631522,0.0001682914,0.0001941107,0.006598743,0.003459376,0.0002116905,0.001370577,0.09038178],"study_design_scores_gemma":[0.008597779,0.03283988,0.860319,0.0002783496,0.003519778,0.0006727051,0.0002320824,0.08620166,0.003111631,0.002448855,0.001623559,0.0001547498],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933555,0.002798196,0.00124706,0.0004273377,0.0001020766,0.0001152971,0.0004048134,0.00006837377,0.001481291],"genre_scores_gemma":[0.9985544,0.0002231066,0.0005882434,0.00009586642,0.00006494724,0.00002927368,0.0003018765,0.000003453589,0.0001386419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007860149,"threshold_uncertainty_score":0.04156893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01958403230995917,"score_gpt":0.3002328244044737,"score_spread":0.2806487920945145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}