{"id":"W4311491456","doi":"10.1186/s12950-022-00323-w","title":"Combination of IL-17A/F and TNF-α uniquely alters the bronchial epithelial cell proteome to enhance proteins that augment neutrophil migration","year":2022,"lang":"en","type":"article","venue":"Journal of Inflammation","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Manitoba; Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"Children's Hospital Research Institute of Manitoba; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Reseau canadien de recherche respiratoire; Research Manitoba","keywords":"Tumor necrosis factor alpha; Chemokine; Immunology; Inflammation; Cytokine; Interleukin 8; Interleukin 17; Lipocalin; Medicine; Cell biology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001244598,0.0003011666,0.0002610337,0.0001395163,0.00008633368,0.0001878442,0.00008622549,0.0001845761,0.001087802],"category_scores_gemma":[0.00007027705,0.00009992679,0.000259373,0.0001135837,0.0001148648,0.000115169,0.0001293679,0.0003214611,0.00033081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00013677,"about_ca_system_score_gemma":0.0001181534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001270498,"about_ca_topic_score_gemma":0.0002585763,"domain_scores_codex":[0.999862,0.00001711921,0.00001086937,0.00003022059,0.00004090028,0.00003893233],"domain_scores_gemma":[0.9999441,0.000008948505,0.00001612747,0.000007269007,0.000008774346,0.00001474771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004058713,0.000008358926,0.0001262715,0.00001278657,0.000002390354,0.00001151042,0.000002116562,0.00001301653,0.9995215,0.000003815986,0.000008115839,0.0002494133],"study_design_scores_gemma":[0.000007425856,0.0002650029,0.00417236,0.000003793414,0.00001373866,0.0001597429,0.00001337023,0.0003559499,0.9940615,0.000007907519,0.0009372527,0.000001947135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961147,0.001058756,0.001834353,0.00006125389,0.00002958157,0.00002465415,0.0002447932,0.0000298846,0.0006020418],"genre_scores_gemma":[0.9929,0.0009325647,0.004020596,0.00008498215,0.00002145092,0.00007654513,0.0005146773,0.00001741911,0.001431675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001087802,"threshold_uncertainty_score":0.003639102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009426494568626004,"score_gpt":0.2224063029849024,"score_spread":0.2129798084162763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}