{"id":"W4311504638","doi":"10.1002/acn3.51695","title":"Plasma phosphorylated tau181 predicts cognitive and functional decline","year":2022,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Norman Cousins Center for Psychoneuroimmunology; National Institute of Neurological Disorders and Stroke; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; H. Lundbeck A/S; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Takeda Pharmaceuticals U.S.A.; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; F. Hoffmann-La Roche; University of Pennsylvania; AbbVie; Roche; University of Southern California; Chan Zuckerberg Initiative; Novartis Pharmaceuticals Corporation; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Drug Discovery Foundation; Merck; Alzheimer's Association; American Heart Association; Foundation for the National Institutes of Health","keywords":"Medicine; Phosphorylation; Cognition; Cognitive decline; Internal medicine; Cell biology; Psychiatry; Disease; Dementia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004607027,0.0004826436,0.0002690119,0.000634938,0.0002287798,0.0004612344,0.0002007833,0.0005081587,0.001258038],"category_scores_gemma":[0.00160639,0.0001782208,0.0001960239,0.0002695133,0.0001723499,0.0002699212,0.0002239352,0.0003051059,0.0004182688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001502456,"about_ca_system_score_gemma":0.0001334633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00106505,"about_ca_topic_score_gemma":0.001078474,"domain_scores_codex":[0.9998912,0.00001850223,0.00001439156,0.00003322882,0.00002772628,0.00001485114],"domain_scores_gemma":[0.99927,0.0001317874,0.0003580206,0.00003078042,0.00009114922,0.0001182997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005396191,0.00007408464,0.9953222,0.00001307323,0.00004535481,0.0001168326,0.00003715956,0.00009320636,0.001148878,0.000008049958,0.0001289308,0.002472604],"study_design_scores_gemma":[0.00001934461,0.0001906508,0.9982557,0.000005329268,0.00002297251,0.0006252261,0.000033055,0.0004163517,0.0002951624,0.00002969965,0.0001042436,0.000002251073],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993398,0.0001548159,0.0000549734,0.00001825098,0.00000370353,0.000004937397,0.0001463619,0.000005623754,0.0002715621],"genre_scores_gemma":[0.9993568,0.00006048354,0.00008590445,0.0000132413,0.00001249437,0.000004984917,0.0002840594,0.000001491406,0.0001805546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001258038,"threshold_uncertainty_score":0.004208565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.114500501642605,"score_gpt":0.4053895741299038,"score_spread":0.2908890724872988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}