{"id":"W4311505203","doi":"10.1111/jnc.15741","title":"Fundamental Neurochemistry Review: Incorporating a greater diversity of cell types, including microglia, in brain organoid cultures improves clinical translation","year":2022,"lang":"en","type":"review","venue":"Journal of Neurochemistry","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Organoid; Neuroscience; Biology; Human brain; Transcriptome; Microglia; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001879544,0.000767638,0.001161861,0.002183389,0.0004177648,0.002374146,0.0009308073,0.001650661,0.009960315],"category_scores_gemma":[0.003052537,0.0003103385,0.0007184809,0.002077058,0.0006316843,0.001803017,0.000969636,0.002569841,0.006001957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001369112,"about_ca_system_score_gemma":0.004451999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001131047,"about_ca_topic_score_gemma":0.001969286,"domain_scores_codex":[0.9993679,0.0001344478,0.0001150548,0.00009566439,0.0002342438,0.00005265454],"domain_scores_gemma":[0.9972019,0.0008577692,0.0002829227,0.0001011226,0.00131921,0.0002371429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001395154,0.00006620611,0.0001419379,0.03690341,0.000141581,0.0002203618,0.00009726323,0.0002028664,0.006222672,0.00769113,0.3127683,0.6354048],"study_design_scores_gemma":[0.00001122612,0.0000551914,0.0002580069,0.002604322,0.00006284761,0.0002216314,0.00002488986,0.00002311289,0.0009416983,0.001131061,0.9946561,0.000009864162],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002514921,0.9795568,0.0007638943,0.005076123,0.008855297,0.00005967239,0.0001917111,0.00005777295,0.005187288],"genre_scores_gemma":[0.001296909,0.9877357,0.0007833884,0.002962437,0.003155212,0.00006401001,0.0002646546,0.00002064633,0.003716984],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.009960315,"threshold_uncertainty_score":0.03332061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1465550261195079,"score_gpt":0.3705895022011638,"score_spread":0.2240344760816559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}