{"id":"W4311518544","doi":"10.3390/brainsci12121666","title":"Converging Evidence Points to BDNF as Biomarker of Depressive Symptoms in Schizophrenia-Spectrum Disorders","year":2022,"lang":"en","type":"article","venue":"Brain Sciences","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health; Dalhousie University","funders":"","keywords":"Schizophrenia (object-oriented programming); Biomarker; Brain-derived neurotrophic factor; Schizoaffective disorder; Psychology; Neurotrophic factors; Clinical psychology; Internal medicine; Major depressive disorder; Oncology; Psychiatry; Neuroplasticity; Bipolar disorder; Psychosis; Medicine; Neuroscience; Mood; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001065579,0.0001101599,0.0001376936,0.0003649012,0.000547829,0.00006437088,0.0007236844,0.00002126919,0.0002863139],"category_scores_gemma":[0.001459865,0.00009680405,0.00004991692,0.001882249,0.0004361341,0.0004484971,0.000330548,0.0001148281,0.00002124408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000045129,"about_ca_system_score_gemma":0.0001596501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001714681,"about_ca_topic_score_gemma":0.0001259256,"domain_scores_codex":[0.9977312,0.0004304376,0.0002912261,0.0005755187,0.0006675525,0.0003040459],"domain_scores_gemma":[0.9988446,0.0007292071,0.000145553,0.0002013764,0.000009282686,0.00006997117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001866841,0.0001070628,0.01091165,0.00001274298,0.00000267391,0.00001883482,0.001186926,0.004507795,0.9512916,0.02258301,0.0008148274,0.008376146],"study_design_scores_gemma":[0.000739183,0.0008176262,0.02398641,0.0001378718,0.000005233708,0.00004257122,0.0004723662,0.01029389,0.9466333,0.01513162,0.001314256,0.0004256696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841012,0.0001518301,0.0001410599,0.01388696,0.0005216115,0.0002888256,0.000008366633,0.00002916947,0.0008709138],"genre_scores_gemma":[0.998028,0.00001417111,0.0001084796,0.001506613,0.00001975183,0.00005486964,4.179666e-7,0.000006137211,0.0002615152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01392678,"threshold_uncertainty_score":0.4213513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03912769672647034,"score_gpt":0.3181448996880965,"score_spread":0.2790172029616262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}