{"id":"W4311525598","doi":"10.1093/ofid/ofac492.065","title":"872. Voriconazole Therapeutic Drug Monitoring (TDM): How Common is Autoinduction?","year":2022,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services; University of Alberta","funders":"","keywords":"Voriconazole; Medicine; Therapeutic drug monitoring; Dosing; Discontinuation; Internal medicine; Pharmacokinetics; Therapeutic index; CYP2C19; Concomitant; Drug; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002217866,0.0002308566,0.0004741953,0.0006125765,0.0002052678,0.001027155,0.0005556306,0.0006793963,0.002209314],"category_scores_gemma":[0.005592268,0.0001296195,0.0002526023,0.00152234,0.000517339,0.0006034151,0.0002906412,0.0005316769,0.0008557152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009135141,"about_ca_system_score_gemma":0.000646219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005419387,"about_ca_topic_score_gemma":0.008778109,"domain_scores_codex":[0.9978265,0.0004858752,0.0003470498,0.0002976324,0.00080356,0.0002393131],"domain_scores_gemma":[0.9945135,0.001199718,0.003068332,0.000172052,0.000741875,0.0003044999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004761276,0.00005255658,0.9009455,0.0001969099,0.00006045236,0.0008826205,0.0001229613,0.0001592543,0.0007755406,0.0002427785,0.003131929,0.09295336],"study_design_scores_gemma":[0.00002278089,0.0003202072,0.976187,0.0004789202,0.000114877,0.009066052,0.0004039477,0.001576284,0.001178098,0.0003808925,0.01025162,0.00001928428],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947488,0.02920533,0.004493724,0.005861637,0.0001822624,0.00006120487,0.001461722,0.0001081439,0.01113786],"genre_scores_gemma":[0.9922792,0.003997291,0.0008145969,0.0009653763,0.0002424111,0.00001732128,0.0007393836,0.00002181894,0.0009225945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005419387,"threshold_uncertainty_score":0.01172936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02077365119182781,"score_gpt":0.3079579463700808,"score_spread":0.2871842951782529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}