{"id":"W4311529030","doi":"10.1101/2022.12.02.518887","title":"GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Medical Research Council; Medical Research Council; Associazione Italiana per la Ricerca sul Cancro; Ministerio de Ciencia, Innovación y Universidades; Institute for Research in Biomedicine; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"SWI/SNF; Motile cilium; Transcription factor; Biology; Cell biology; Cilium; Ciliogenesis; Transcriptional regulation; SMARCA4; ARID1A; Transcription (linguistics); Gene; Genetics; Chromatin remodeling; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001720562,0.0003333414,0.0001799389,0.0002594455,0.0003456766,0.000427873,0.0002522932,0.0003350654,0.00153707],"category_scores_gemma":[0.0001341539,0.0002599856,0.0002145765,0.0001427628,0.0003054127,0.0001842341,0.0003338617,0.0005388462,0.0007291221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007194943,"about_ca_system_score_gemma":0.0002486309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001243258,"about_ca_topic_score_gemma":0.002737431,"domain_scores_codex":[0.9998139,0.0000184434,0.000008954091,0.00005522527,0.00005457022,0.00004897324],"domain_scores_gemma":[0.9998882,0.00001166639,0.000023875,0.00001153943,0.0000110373,0.00005368629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001054101,0.00001085107,0.0004500096,0.00001965153,0.000003633764,0.00003676561,0.00001247541,0.00004278088,0.9984872,0.0001345551,0.00008259343,0.0006139462],"study_design_scores_gemma":[0.00001522297,0.00006887994,0.02332393,0.000005151825,0.000005242286,0.0001267634,0.00005071323,0.001412806,0.972555,0.00004888378,0.002382896,0.000004635961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941366,0.001709359,0.001496334,0.0001340375,0.00002815855,0.00001503851,0.0003360018,0.0001024435,0.002042008],"genre_scores_gemma":[0.9935069,0.0003102792,0.001372784,0.00005842274,0.000007552303,0.00002057533,0.0009456396,0.00002939529,0.003748501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00153707,"threshold_uncertainty_score":0.005220294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01470254772303168,"score_gpt":0.2352079554314062,"score_spread":0.2205054077083746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}