{"id":"W4311529030","doi":"10.1101/2022.12.02.518887","title":"GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Medical Research Council; Medical Research Council; Associazione Italiana per la Ricerca sul Cancro; Ministerio de Ciencia, Innovación y Universidades; Institute for Research in Biomedicine; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"SWI/SNF; Motile cilium; Transcription factor; Biology; Cell biology; Cilium; Ciliogenesis; Transcriptional regulation; SMARCA4; ARID1A; Transcription (linguistics); Gene; Genetics; Chromatin remodeling; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002412484,0.0004026317,0.0002787969,0.00006904855,0.0003786025,0.000175998,0.0003698956,0.0001965695,0.00008896337],"category_scores_gemma":[0.00001436957,0.0003309255,0.0001240501,0.0001748638,0.0002180715,0.000007556326,0.0002887279,0.0005884119,0.000004337781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008584498,"about_ca_system_score_gemma":0.000263693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005784949,"about_ca_topic_score_gemma":0.00001215134,"domain_scores_codex":[0.9980833,0.000130238,0.0003356659,0.0008309982,0.0002807065,0.0003390917],"domain_scores_gemma":[0.9985124,0.00001981036,0.000223573,0.0008716386,0.0002499651,0.0001225671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001356284,0.000205728,0.0006721554,0.0001413089,0.0001755694,0.000007719649,0.00002266623,0.00178447,0.9955474,0.00007704852,0.001214206,0.00001614363],"study_design_scores_gemma":[0.002648883,0.0006078408,0.07664609,0.0003903962,0.0003681483,6.769844e-7,0.00008165565,0.006844693,0.5164857,0.000006756377,0.3939719,0.001947299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916044,0.005062454,0.001337825,0.0002566956,0.0004590166,0.0008323419,0.0002761564,0.0001448628,0.00002620559],"genre_scores_gemma":[0.9938592,0.0007731571,0.004257096,0.0001351222,0.0003081412,0.0005241968,0.000009587149,0.00009290309,0.00004059655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4790617,"threshold_uncertainty_score":0.9999143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01470254772303168,"score_gpt":0.2352079554314062,"score_spread":0.2205054077083746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}