{"id":"W4311557470","doi":"10.1021/jacs.2c09870","title":"Three on Three: Universal and High-Affinity Molecular Recognition of the Symmetric Homotrimeric Spike Protein of SARS-CoV-2 with a Symmetric Homotrimeric Aptamer","year":2022,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; Public Health Ontario; McMaster University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Canada Foundation for Innovation","keywords":"Chemistry; Spike (software development); Molecular recognition; Molecule; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004402007,0.0007357853,0.000715011,0.0004469384,0.0005146452,0.0005936971,0.0008385877,0.001048125,0.01277774],"category_scores_gemma":[0.0006345284,0.0002997075,0.000597697,0.0002056647,0.0005119487,0.0003855586,0.0008164778,0.0006271686,0.001918163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007320787,"about_ca_system_score_gemma":0.0004828889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001095689,"about_ca_topic_score_gemma":0.001755404,"domain_scores_codex":[0.9989428,0.0001001605,0.00008670889,0.0002850411,0.0003452291,0.0002400804],"domain_scores_gemma":[0.9996014,0.00006920219,0.00003544311,0.0000815727,0.0001082126,0.0001042441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006509662,0.0002685231,0.0009796235,0.00007607232,0.00002510264,0.00005619078,0.00003221212,0.0001459621,0.9863644,0.0002164816,0.0005669918,0.01061762],"study_design_scores_gemma":[0.00007885365,0.001104858,0.003697564,0.000004846975,0.00002643474,0.0001752226,0.00003262033,0.001671086,0.9900148,0.0001357189,0.003036795,0.00002124847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722533,0.0002944275,0.01611831,0.0002694521,0.0002577626,0.000609446,0.001027506,0.0006230058,0.008546861],"genre_scores_gemma":[0.9590415,0.0002205596,0.01857161,0.0003637537,0.00003890696,0.000548606,0.001872682,0.00009971063,0.01924261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01277774,"threshold_uncertainty_score":0.04274583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01263969007554729,"score_gpt":0.2435638668079613,"score_spread":0.230924176732414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}