{"id":"W4311577549","doi":"10.1186/s12969-022-00768-6","title":"First-line options for systemic juvenile idiopathic arthritis treatment: an observational study of Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans","year":2022,"lang":"en","type":"article","venue":"Pediatric Rheumatology","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Genentech; National Institutes of Health; Patient-Centered Outcomes Research Institute; Arthritis Foundation","keywords":"Medicine; Rheumatology; Observational study; Internal medicine; Arthritis; Canakinumab; Methotrexate; Pediatrics; Disease; Anakinra","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001217825,0.0003062614,0.001681162,0.0005127428,0.001046187,0.00001949373,0.0002079738,0.0001712798,0.0001514955],"category_scores_gemma":[0.0004324655,0.0002979627,0.0001367435,0.0005818478,0.0002254489,0.00007701881,0.0001239418,0.0003631477,0.00001415477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003124905,"about_ca_system_score_gemma":0.00133597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001555989,"about_ca_topic_score_gemma":0.001181752,"domain_scores_codex":[0.9957036,0.0007931873,0.001541596,0.0007308638,0.0005210925,0.0007097067],"domain_scores_gemma":[0.9974327,0.0009668709,0.000416344,0.0006149053,0.0003654316,0.0002037627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001526574,0.01078716,0.9556114,0.0007402464,0.0005437907,0.0004087503,0.01054529,0.0009930508,0.00006121063,0.003385796,0.000950986,0.01444575],"study_design_scores_gemma":[0.1702175,0.1729255,0.4928229,0.001045464,0.0009638166,0.05782386,0.06725476,0.01468535,0.0001332885,0.004304189,0.0155671,0.002256245],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9503964,0.04431065,0.00003038329,0.001473233,0.0001573869,0.003246993,0.0002875887,0.00007508297,0.00002235121],"genre_scores_gemma":[0.9400638,0.05583806,0.0001579166,0.00001439411,0.00003812934,0.003391926,0.000280282,0.0000495175,0.0001660165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4627885,"threshold_uncertainty_score":0.9999472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1057294923824289,"score_gpt":0.3572766321923907,"score_spread":0.2515471398099618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}