{"id":"W4311580809","doi":"10.1177/12034754221141680","title":"Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway","year":2022,"lang":"en","type":"review","venue":"Journal of Cutaneous Medicine and Surgery","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Dermatrials Research; University of British Columbia; SKiN Health; University of Alberta; University of Calgary; University of Toronto; Dalhousie University; Innovaderm (Canada); Probity Medical Research","funders":"","keywords":"Janus kinase; Psoriasis; Medicine; Tyrosine kinase 2; Tofacitinib; JAK-STAT signaling pathway; STAT protein; stat; Pharmacology; Tyrosine kinase; Immunology; Cancer research; Signal transduction; Cytokine; Internal medicine; STAT3; Receptor; Biology; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001124279,0.0003789855,0.0005660078,0.0002982361,0.0002052132,0.0009142224,0.0002546675,0.000826162,0.004279434],"category_scores_gemma":[0.001065245,0.0001063429,0.0004324952,0.0002338398,0.000562426,0.0007407019,0.0004041471,0.002331797,0.001053612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004068683,"about_ca_system_score_gemma":0.0006258514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003084262,"about_ca_topic_score_gemma":0.001120781,"domain_scores_codex":[0.9996976,0.0001097977,0.00002900852,0.00003623642,0.00009030962,0.00003710904],"domain_scores_gemma":[0.9994532,0.0002315798,0.00006549568,0.00002870601,0.0001163861,0.000104526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002391701,0.0005161345,0.004109916,0.002917865,0.0001400539,0.00198743,0.0001476745,0.0006726089,0.02454592,0.008950694,0.05821649,0.8954037],"study_design_scores_gemma":[0.003142603,0.00618981,0.02205706,0.005000068,0.0003873628,0.0175414,0.000401312,0.00314643,0.01724019,0.02212705,0.9026548,0.0001119842],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02639344,0.8840944,0.002564074,0.05686609,0.003872904,0.00006839292,0.000133915,0.00009442905,0.02591242],"genre_scores_gemma":[0.2284592,0.7119521,0.004700923,0.02407489,0.01751025,0.0001443798,0.0002396844,0.00005835339,0.01286023],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004279434,"threshold_uncertainty_score":0.01431614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09426026995532921,"score_gpt":0.3381719767932764,"score_spread":0.2439117068379472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}