{"id":"W4311581561","doi":"10.1186/s13024-022-00586-0","title":"Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer’s disease continuum","year":2022,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"HORIZON EUROPE Marie Sklodowska-Curie Actions; National Institute on Aging; Olav Thon Stiftelsen; Marcus och Amalia Wallenbergs minnesfond; H2020 European Research Council; Gun och Bertil Stohnes Stiftelse; Skånes universitetssjukhus; Alzheimer's Drug Discovery Foundation; Alzheimerfonden; Agneta Prytz-Folkes och Gösta Folkes Stiftelse; Göteborgs Universitet; Knut och Alice Wallenbergs Stiftelse; Parkinsonfonden; Hjärnfonden; Familjen Erling-Perssons Stiftelse; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Lunds Universitet; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Anna-Lisa och Bror Björnssons Stiftelse; Svenska Forskningsrådet Formas; EU Joint Programme – Neurodegenerative Disease Research; UK Dementia Research Institute; Vetenskapsrådet; Demensförbundet; BrightFocus Foundation","keywords":"Epitope; Dementia; Cerebrospinal fluid; Biomarker; Disease; Alzheimer's disease; Neurology; Antibody; Medicine; Frontotemporal dementia; Pathology; Internal medicine; Oncology; Immunology; Chemistry; Psychiatry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003975415,0.0001842497,0.0001964639,0.00005524288,0.0004920523,0.00003959683,0.0002062474,0.00002500127,0.0001106596],"category_scores_gemma":[0.000123982,0.0001496498,0.0001860392,0.0002738491,0.00008835064,0.00007866939,0.0002082468,0.0001759879,0.00001073245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001001483,"about_ca_system_score_gemma":0.0002839012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006813688,"about_ca_topic_score_gemma":0.00001360411,"domain_scores_codex":[0.9971858,0.0002829336,0.0003108102,0.0003728191,0.001528985,0.0003186345],"domain_scores_gemma":[0.9985468,0.00001396131,0.0001316737,0.0007734379,0.0003116312,0.0002225371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002868966,0.001890271,0.02949022,0.00008360168,0.002797615,0.000564339,0.0004289337,0.002306574,0.9512723,0.0005748951,0.004532139,0.003190167],"study_design_scores_gemma":[0.006427387,0.001671603,0.3192301,0.00004250717,0.002307514,0.00005177495,0.0001420992,0.007460226,0.6600017,0.0003974078,0.001857527,0.0004101603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818059,0.01242278,0.001515036,0.002462555,0.0002044716,0.001244018,0.0001694517,0.0000477124,0.0001280293],"genre_scores_gemma":[0.9984347,0.00004411813,0.00007641152,0.0004387852,0.00006788762,0.0002011651,0.0006724814,0.00003719662,0.00002724346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2912706,"threshold_uncertainty_score":0.6102543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03146786598098737,"score_gpt":0.3093787863917689,"score_spread":0.2779109204107815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}