{"id":"W4311585062","doi":"10.1128/spectrum.03729-22","title":"Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates of <i>Achromobacter</i> Species and Correlate with Modifications of the Lipid A Moiety of Lipopolysaccharide","year":2022,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Infections and bacterial resistance","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Queen's University; UK Research and Innovation; Cystic Fibrosis Foundation","keywords":"Polymyxin; Lipid A; Achromobacter; Microbiology; Moiety; Biology; Lipopolysaccharide; Polymyxin B; Bacteria; Chemistry; Antibiotics; Pseudomonas; Genetics; Stereochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002875433,0.0003343669,0.000372483,0.0006652155,0.0002899197,0.0004796178,0.0002164687,0.0004339034,0.002756517],"category_scores_gemma":[0.00211107,0.0001512809,0.0001989702,0.0007776553,0.0004554984,0.0003164581,0.0003704565,0.0004317721,0.0004825017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001669878,"about_ca_system_score_gemma":0.0001703793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001090514,"about_ca_topic_score_gemma":0.0008267392,"domain_scores_codex":[0.9993956,0.00008903934,0.00009662871,0.0001472666,0.0001616317,0.0001098157],"domain_scores_gemma":[0.9973483,0.0003763577,0.001611706,0.0001432674,0.0002372614,0.0002830608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005660278,0.0001984201,0.9064655,0.0001906857,0.0000621876,0.005538063,0.0005426912,0.00005785471,0.0667616,0.0001728096,0.0006301908,0.01881409],"study_design_scores_gemma":[0.00001171249,0.000486279,0.965182,0.00003680449,0.00004401915,0.02486685,0.0007172735,0.00008884161,0.006846001,0.0001442078,0.001562786,0.00001328068],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960093,0.0008910658,0.000391687,0.0001952699,0.000009810271,0.00002696016,0.0002533205,0.00002240357,0.002200133],"genre_scores_gemma":[0.9989542,0.0002530063,0.0002578813,0.00007361099,0.00001463302,0.00000696551,0.0001692435,0.00000634255,0.0002641857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002756517,"threshold_uncertainty_score":0.009221435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006593917295420392,"score_gpt":0.2167750808355096,"score_spread":0.2101811635400892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}