{"id":"W4311585062","doi":"10.1128/spectrum.03729-22","title":"Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates of <i>Achromobacter</i> Species and Correlate with Modifications of the Lipid A Moiety of Lipopolysaccharide","year":2022,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Infections and bacterial resistance","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Queen's University; UK Research and Innovation; Cystic Fibrosis Foundation","keywords":"Polymyxin; Lipid A; Achromobacter; Microbiology; Moiety; Biology; Lipopolysaccharide; Polymyxin B; Bacteria; Chemistry; Antibiotics; Pseudomonas; Genetics; Stereochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001850154,0.0001132899,0.0003008723,0.00003924222,0.00009693423,0.00000397376,0.0001650433,0.00008460645,0.00001007244],"category_scores_gemma":[0.00002539026,0.00008801946,0.00006403303,0.0001205432,0.00063779,0.00000397299,0.0001837802,0.0001571399,6.739475e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000013933,"about_ca_system_score_gemma":0.00004647073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000743467,"about_ca_topic_score_gemma":0.003438237,"domain_scores_codex":[0.9989529,0.0001817382,0.0004254867,0.0002612888,0.00003198421,0.0001466261],"domain_scores_gemma":[0.9991539,0.00004300041,0.0004167913,0.0003341794,0.00003299875,0.00001918222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005028373,0.0001096465,0.09800211,0.00003601831,0.00004008167,4.922392e-7,0.00006030382,0.0000108561,0.9005654,0.0005510784,0.0001014262,0.00001970278],"study_design_scores_gemma":[0.0009706033,0.0005352513,0.4457365,0.00007707052,0.00003566199,0.0000386728,0.0002121836,0.000005880712,0.5479881,0.0001328371,0.004099005,0.0001682273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978861,0.001048105,0.00002698683,0.000346662,0.000100133,0.0001678508,0.0003238363,0.000002622745,0.00009776578],"genre_scores_gemma":[0.9990401,0.0003548417,0.0001132344,0.0000504071,0.00002211084,0.00001234231,0.00001956197,0.000009500108,0.0003778599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3525774,"threshold_uncertainty_score":0.3589329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006593917295420392,"score_gpt":0.2167750808355096,"score_spread":0.2101811635400892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}