{"id":"W4311605650","doi":"10.1101/2022.12.15.520595","title":"Grid cell disruption in a mouse model of early Alzheimer’s disease reflects reduced integration of self-motion cues and increased influence of environmental geometry","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Deutsche Forschungsgemeinschaft","keywords":"Path integration; Grid cell; Neuroscience; Grid; Coding (social sciences); Sensory cue; Psychology; Biology; Computer science; Geometry; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002589686,0.0009391597,0.0004669226,0.001756509,0.0003280531,0.0005950618,0.0004397579,0.0007175704,0.003113015],"category_scores_gemma":[0.0001645982,0.000435951,0.0004187672,0.0005867402,0.0005617204,0.0003834265,0.0004142492,0.001410792,0.0008527999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000466693,"about_ca_system_score_gemma":0.0002969175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001816024,"about_ca_topic_score_gemma":0.003048533,"domain_scores_codex":[0.9997731,0.00002378086,0.00002759728,0.00006525213,0.00006482991,0.00004540408],"domain_scores_gemma":[0.9996341,0.00003148201,0.0001652526,0.00003815883,0.00003252254,0.00009837935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004210932,0.0001627187,0.0007852147,0.00003950763,0.00001944909,0.0002460227,0.00006857124,0.0001271766,0.995911,0.0003532243,0.0001982374,0.001667748],"study_design_scores_gemma":[0.0002467553,0.001024283,0.02625395,0.00004265288,0.0001146051,0.001801047,0.0002644734,0.004295019,0.9592984,0.001044479,0.005579144,0.00003521681],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986357,0.0007104004,0.008201079,0.0002785693,0.00007530589,0.00004820202,0.002072534,0.0004688393,0.001788142],"genre_scores_gemma":[0.9727956,0.0009170297,0.01180058,0.0001430035,0.00002101125,0.0001704475,0.001801063,0.0002201008,0.01213114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003113015,"threshold_uncertainty_score":0.010414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02129776792856226,"score_gpt":0.2668317209154815,"score_spread":0.2455339529869192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}