{"id":"W4311615005","doi":"10.1093/ofid/ofac492.021","title":"730. A Phase 3, Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Ridinilazole Compared with Vancomycin for the Treatment of <i>Clostridioides difficile</i> Infection","year":2022,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Clinical endpoint; Medicine; Clostridium difficile; Microbiome; Internal medicine; Adverse effect; Population; Diarrhea; Antibiotics; Vancomycin; Clostridioides; Randomized controlled trial; Gastroenterology; Microbiology; Biology; Bacteria; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009188298,0.0003520018,0.001178771,0.0001947284,0.001049498,0.00009852729,0.0003091314,0.00002828227,0.0001574973],"category_scores_gemma":[0.0002166249,0.0001871278,0.0003170965,0.0007833722,0.0003077635,0.00008472923,0.0003707954,0.0001670755,0.000002343473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002983968,"about_ca_system_score_gemma":0.0004259396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002664505,"about_ca_topic_score_gemma":0.0005977316,"domain_scores_codex":[0.997253,0.0004102579,0.0007109828,0.000490446,0.0007157858,0.0004195482],"domain_scores_gemma":[0.9962776,0.002126321,0.0002716978,0.0007605161,0.0003457676,0.0002180754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9254149,0.026258,0.02750959,0.0001033566,0.002370381,0.00001179419,0.001766482,0.00486282,0.0008950543,0.0002244743,0.001139638,0.009443471],"study_design_scores_gemma":[0.9303156,0.03421671,0.004302941,0.00009140416,0.004625833,0.00006281699,0.004311339,0.001258162,0.01409356,0.00004985932,0.006330231,0.0003415613],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728897,0.0009992882,0.0001276979,0.001086866,0.0001491028,0.02377048,0.0003930241,0.0000374514,0.0005463804],"genre_scores_gemma":[0.9938855,0.000432878,0.000009356502,0.00009088461,0.00007705651,0.005171812,0.00009972859,0.00004734479,0.0001854907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02320664,"threshold_uncertainty_score":0.8071997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04735378177435139,"score_gpt":0.3718748085574499,"score_spread":0.3245210267830985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}