{"id":"W4311615005","doi":"10.1093/ofid/ofac492.021","title":"730. A Phase 3, Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Ridinilazole Compared with Vancomycin for the Treatment of <i>Clostridioides difficile</i> Infection","year":2022,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Clinical endpoint; Medicine; Clostridium difficile; Microbiome; Internal medicine; Adverse effect; Population; Diarrhea; Antibiotics; Vancomycin; Clostridioides; Randomized controlled trial; Gastroenterology; Microbiology; Biology; Bacteria; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001990439,0.001594559,0.00279701,0.0004232444,0.000551484,0.0009374535,0.0008513713,0.001621964,0.009960785],"category_scores_gemma":[0.001581735,0.0007505947,0.001441626,0.0004679943,0.001347893,0.0008225262,0.0003039551,0.002537101,0.001464706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009730532,"about_ca_system_score_gemma":0.002176187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001487111,"about_ca_topic_score_gemma":0.003525327,"domain_scores_codex":[0.9991583,0.0004617483,0.00004436867,0.0001419562,0.00005919861,0.0001343816],"domain_scores_gemma":[0.9990225,0.0002389617,0.0002201343,0.00006444701,0.00008595708,0.0003680591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9779686,0.00791112,0.000294368,0.0003214265,0.000378958,0.00002110387,0.00002624676,0.0001401581,0.004126936,0.00007535471,0.0008009751,0.007934644],"study_design_scores_gemma":[0.874206,0.1232707,0.001154125,0.00001750811,0.0002381363,0.00001590771,0.00001183846,0.0002383719,0.000346575,0.00007070816,0.000418717,0.0000113542],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793614,0.00277064,0.001053633,0.000549349,0.0005814685,0.009468569,0.002639776,0.0002885795,0.003286635],"genre_scores_gemma":[0.9774562,0.001664463,0.002775781,0.001608964,0.0004498834,0.009718766,0.001698918,0.00005222109,0.004574933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009960785,"threshold_uncertainty_score":0.0333221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04735378177435139,"score_gpt":0.3718748085574499,"score_spread":0.3245210267830985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}