{"id":"W4311619430","doi":"10.1101/2022.12.03.519003","title":"Determinants of natriuretic, diuretic, and kaliuretic effects of diuretics: Sex and administration time","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Diuretic; Thiazide; Endocrinology; Internal medicine; Blood pressure; Renal function; Natriuresis; Medicine; Chronotherapy (sleep phase)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000213335,0.0002090644,0.0002662887,0.0001329719,0.00009797843,0.0004817914,0.0003380555,0.0003005613,0.002067092],"category_scores_gemma":[0.0008190833,0.0001319957,0.0003633094,0.0001414285,0.0001826901,0.0002316679,0.0001968704,0.0002272736,0.0001528463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002219065,"about_ca_system_score_gemma":0.0003091298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00186263,"about_ca_topic_score_gemma":0.001409555,"domain_scores_codex":[0.9999157,0.0000192035,0.000006054112,0.00002349326,0.00001728776,0.0000182119],"domain_scores_gemma":[0.9995678,0.0001894187,0.00009756252,0.00003010379,0.00005383923,0.00006119238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.001754254,0.0005261056,0.2070594,0.0002780786,0.0003897779,0.0004821385,0.0001023301,0.5001006,0.2653119,0.003799933,0.0008827466,0.0193128],"study_design_scores_gemma":[0.0001352161,0.00105942,0.1276985,0.0000237903,0.0002479914,0.0003507051,0.0001591361,0.8174521,0.04850022,0.002072768,0.002227997,0.0000722344],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945748,0.0001696658,0.004027142,0.00004767782,0.000009480595,0.000009245199,0.0003443303,0.00002604386,0.0007914994],"genre_scores_gemma":[0.9983954,0.0000839624,0.000894957,0.00001657005,0.00000168112,0.000008986499,0.0001692437,0.00001589641,0.0004132434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002067092,"threshold_uncertainty_score":0.006915092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009085137737066316,"score_gpt":0.2245469182979139,"score_spread":0.2154617805608476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}